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American Journal of Clinical Nutrition, Vol 62, 1357S-1364S, Copyright © 1995 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Coantioxidants make alpha-tocopherol an efficient antioxidant for low- density lipoprotein

SR Thomas, J Neuzil, D Mohr and R Stocker
Biochemistry Group, Heart Research Institute, Camperdown, Sydney, New South Wales, Australia.

The oxidation of low-density lipoproteins (LDLs) is now commonly implicated as an important early event in atherogenesis. The resulting interest in LDL antioxidation has focused on alpha-tocopherol, the biologically and chemically most active form of vitamin E and quantitatively the major lipid-soluble antioxidant in extracts prepared from human LDL. We review advances made in our understanding of the molecular action of alpha-tocopherol in radical-mediated oxidation of isolated human LDL and how the vitamin's antioxidant activity is enhanced or even dependent on the presence of suitable reducing species, which are referred to as coantioxidants.


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