American Journal of Clinical Nutrition, Vol 62, 1365S-1369S, Copyright © 1995 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Epidemiologic evidence for vitamin E in prevention of cardiovascular disease

MJ Stampfer and EB Rimm
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.

Ecologic studies of vitamin E have shown that regions with relatively low dietary vitamin E tend to have higher rates of coronary heart disease (CHD), but it is difficult to adjust for other risk factors. Cross-sectional studies in individuals have yielded conflicting results, as have prospective studies based on stored blood samples. Two large prospective studies found that persons who had used vitamin E supplements for > or = 2 y had approximately 40% lower rates of CHD. Short durations and doses of < 100 IU/d had no significant effect. The effect of dietary vitamin E was modest and nonsignificant. Adjustment for a wide array of other coronary risk factors had little effect on the findings, which were specific for vitamin E and not other supplements. The only large, randomized trial found no material reduction in CHD risk for 50 IU vitamin E/d. The epidemiologic evidence suggests that high doses of vitamin E may reduce the risk of CHD.

This article has been cited by other articles:

				S. Hercberg, P. Galan, P. Preziosi, S. Bertrais, L. Mennen, D. Malvy, A.-M. Roussel, A. Favier, and S. Briancon The SU.VI.MAX Study: A Randomized, Placebo-Controlled Trial of the Health Effects of Antioxidant Vitamins and Minerals Arch Intern Med, November 22, 2004; 164(21): 2335 - 2342. [Abstract] [Full Text] [PDF]

				W. Wouters-Wesseling, L. W. Wagenaar, L. C.P.G.M. de Groot, J. G. Bindels, and W. A. van Staveren Biochemical Antioxidant Levels Respond to Supplementation with an Enriched Drink in Frail Elderly People J. Am. Coll. Nutr., June 1, 2003; 22(3): 232 - 238. [Abstract] [Full Text] [PDF]

				G. D. Plotnick, M. C. Corretti, R. A. Vogel, R. Hesslink Jr, and J. A. Wise Effect of supplemental phytonutrients on impairment of the flow-mediated brachialartery vasoactivity after a single high-fat meal J. Am. Coll. Cardiol., May 21, 2003; 41(10): 1744 - 1749. [Abstract] [Full Text] [PDF]

				P. B. Gorelick Stroke Prevention Therapy Beyond Antithrombotics: Unifying Mechanisms in Ischemic Stroke Pathogenesis and Implications for Therapy: An Invited Review Stroke, March 1, 2002; 33(3): 862 - 875. [Abstract] [Full Text] [PDF]

				R. B. Weinberg, B. S. VanderWerken, R. A. Anderson, J. E. Stegner, and M. J. Thomas Pro-Oxidant Effect of Vitamin E in Cigarette Smokers Consuming a High Polyunsaturated Fat Diet Arterioscler. Thromb. Vasc. Biol., June 1, 2001; 21(6): 1029 - 1033. [Abstract] [Full Text] [PDF]

				E. Bourdon, N. Loreau, J. Davignon, L. Bernier, and D. Blache Involvement of Oxysterols and Lysophosphatidylcholine in the Oxidized LDL-Induced Impairment of Serum Albumin Synthesis by HEPG2 Cells Arterioscler. Thromb. Vasc. Biol., December 1, 2000; 20(12): 2643 - 2650. [Abstract] [Full Text] [PDF]

				A. Ascherio, E. B. Rimm, M. A. Hernan, E. Giovannucci, I. Kawachi, M. J. Stampfer, and W. C. Willett Relation of Consumption of Vitamin E, Vitamin C, and Carotenoids to Risk for Stroke among Men in the United States Ann Intern Med, June 15, 1999; 130(12): 963 - 970. [Abstract] [Full Text] [PDF]

				E. BOURDON, N. LOREAU, and D. BLACHE Glucose and free radicals impair the antioxidant properties of serum albumin FASEB J, February 1, 1999; 13(2): 233 - 244. [Abstract] [Full Text]

				P. Preziosi, P. Galan, B. Herbeth, P. Valeix, A.-M. Roussel, D. Malvy, A. Paul-Dauphin, J. Arnaud, M.-J. Richard, S. Briancon, et al. Effects of Supplementation with a Combination of Antioxidant Vitamins and Trace Elements, at Nutritional Doses, on Biochemical Indicators and Markers of the Antioxidant System in Adult Subjects J. Am. Coll. Nutr., June 1, 1998; 17(3): 244 - 249. [Abstract] [Full Text] [PDF]