American Journal of Clinical Nutrition, Vol 63, 87-95, Copyright © 1996 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Associations between dietary factors and serum lipids by apolipoprotein E polymorphism

JA Marshall, MI Kamboh, DH Bessesen, S Hoag, RF Hamman and RE Ferrell
Department of Preventive Medicine and Biometrics, University of Colorado School of Medicine, Denver, USA.

A geographically based observational study of 852 nondiabetic Hispanic and non-Hispanic white persons in southern Colorado aged 20-74 y was conducted to determine whether diet-lipid associations were modified by the apolipoprotein E (apoE, protein; APOE, gene) polymorphism. Subjects were seen for up to three visits from 1984 to 1992. A 24-h diet recall was collected and fasting serum lipid concentrations were measured at all visits. In longitudinal-regression analyses, dietary factors were significantly associated with serum lipid concentrations in the directions expected based on the large amount of literature on this topic. The positive relation between dietary cholesterol and serum total and low-density-lipoprotein cholesterol was strongest in Hispanic subjects with the APOE*2 allele (E2/ 2,3/2 genotypes) and non-Hispanic white subjects with the APOE*3 allele (E3/3 genotype), and there was no association in subjects with the APOE*4 allele (E4/3, 4/4 genotypes) in either ethnic group. No other statistically significant differences in the relations between dietary factors and serum lipid concentrations by APOE polymorphism were identified. These findings suggest that the APOE polymorphism plays only a minor role in modifying the association between dietary factors and serum lipids.

This article has been cited by other articles:

				A. T Erkkila, E. S Sarkkinen, V. Lindi, S. Lehto, M. Laakso, and M. I. Uusitupa APOE polymorphism and the hypertriglyceridemic effect of dietary sucrose Am. J. Clinical Nutrition, April 1, 2001; 73(4): 746 - 752. [Abstract] [Full Text] [PDF]

				M. Rantala, T. T Rantala, M. J Savolainen, Y. Friedlander, and Y A. Kesaniemi Apolipoprotein B gene polymorphisms and serum lipids: meta-analysis of the role of genetic variation in responsiveness to diet Am. J. Clinical Nutrition, March 1, 2000; 71(3): 713 - 724. [Abstract] [Full Text] [PDF]

				A. Bhargava, J. A Marshall, and R. H Jones Improving power with repeated measures Am. J. Clinical Nutrition, February 1, 1999; 69(2): 338 - 339. [Full Text] [PDF]

				J. M. A. Boer, C. Ehnholm, H.-J. Menzel, L. M. Havekes, M. Rosseneu, D. S. J. O'Reilly, L. Tiret, and f. t. E. Group Interactions Between Lifestyle-Related Factors and the ApoE Polymorphism on Plasma Lipids and Apolipoproteins : The EARS Study Arterioscler. Thromb. Vasc. Biol., September 1, 1997; 17(9): 1675 - 1681. [Abstract] [Full Text]