AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fotouhi, N.
Right arrow Articles by Gaziano, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fotouhi, N.
Right arrow Articles by Gaziano, J. M.
Agricola
Right arrow Articles by Fotouhi, N.
Right arrow Articles by Gaziano, J. M.

American Journal of Clinical Nutrition, Vol 63, 553-558, Copyright © 1996 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Carotenoid and tocopherol concentrations in plasma, peripheral blood mononuclear cells, and red blood cells after long-term beta-carotene supplementation in men

N Fotouhi, M Meydani, MS Santos, SN Meydani, CH Hennekens and JM Gaziano
US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 02111, U.S.A.

To determine the effects of long-term beta-carotene supplementation on concentrations of carotenoids and tocopherols in plasma and in blood cells, fasting blood was collected from 73 randomly selected physicians from the Boston area who are participating in the Physicians Health Study (PHS). The PHS is a randomized, placebo-controlled, double-blind study. In 1982, 22,071 male physicians were assigned to one of four treatments (325 mg aspirin alone, 50 mg beta-carotene alone, both, or neither) every other day. Plasma, peripheral blood mononuclear cells (PBMCs), and red blood cells (RBCs) from physicians who have participated in the study for approximately 12 y were analyzed for carotenoids and tocopherols. Compared with the placebo group, the supplemented group had higher beta-carotene concentrations in plasma (1.73+/-0.16 compared with 0.54+/-0.06 micromol/L0, RBCs (91.5+/-9.7 compared with 31.2+/-4.2 pmol/g hemoglobin), and PBMCs (61.6+/-10.3 compared with 15.5+/-2.5 pmol/10(7) cells). There were no differences in other carotenoids or tocopherols in plasma, RBCs, and PBMCs between these two groups. The beta-carotene concentrations. Plasma cryptoxanthin correlated with both RBC and PBMC cryptoxanthin concentrations but plasma lycopene correlated only with PBMC lycopene concentrations. These data suggest that plasma may not be the best indicator of carotenoid status. Furthermore, long-term beta-carotene supplementation in men results in higher beta-carotene concentrations in plasma, RBCs and PBMCs without lowering concentrations of other carotenoids or tocopherols.


This article has been cited by other articles:


Home page
 Arch OphthalmolHome page
W. G. Christen, J. E. Manson, R. J. Glynn, J. M. Gaziano, E. Y. Chew, J. E. Buring, and C. H. Hennekens
Beta Carotene Supplementation and Age-Related Maculopathy in a Randomized Trial of US Physicians
Arch Ophthalmol, March 1, 2007; 125(3): 333 - 339.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
A. E. Hak, J. Ma, C. B. Powell, H. Campos, J. M. Gaziano, W. C. Willett, and M. J. Stampfer
Prospective Study of Plasma Carotenoids and Tocopherols in Relation to Risk of Ischemic Stroke
Stroke, July 1, 2004; 35(7): 1584 - 1588.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. E. Hak, M. J. Stampfer, H. Campos, H. D. Sesso, J. M. Gaziano, W. Willett, and J. Ma
Plasma Carotenoids and Tocopherols and Risk of Myocardial Infarction in a Low-Risk Population of US Male Physicians
Circulation, August 19, 2003; 108(7): 802 - 807.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
W. G. Christen, J. E. Manson, R. J. Glynn, J. M. Gaziano, R. D. Sperduto, J. E. Buring, and C. H. Hennekens
A Randomized Trial of Beta Carotene and Age-Related Cataract in US Physicians
Arch Ophthalmol, March 1, 2003; 121(3): 372 - 378.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
V. Tyssandier, N. Cardinault, C. Caris-Veyrat, M.-J. Amiot, P. Grolier, C. Bouteloup, V. Azais-Braesco, and P. Borel
Vegetable-borne lutein, lycopene, and {beta}-carotene compete for incorporation into chylomicrons, with no adverse effect on the medium-term (3-wk) plasma status of carotenoids in humans
Am. J. Clinical Nutrition, March 1, 2002; 75(3): 526 - 534.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. Riedl, J. Linseisen, J. Hoffmann, and G. Wolfram
Some Dietary Fibers Reduce the Absorption of Carotenoids in Women
J. Nutr., December 1, 1999; 129(12): 2170 - 2176.
[Abstract] [Full Text]

Home page
 Am. J. Clin. Nutr.Home page
K. H van het Hof, I. A Brouwer, C. E West, E. Haddeman, R. P. Steegers-Theunissen, M. van Dusseldorp, J. A Weststrate, T. K. Eskes, and J. G. Hautvast
Bioavailability of lutein from vegetables is 5 times higher than that of {beta}-carotene
Am. J. Clinical Nutrition, August 1, 1999; 70(2): 261 - 268.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. H. Gann, J. Ma, E. Giovannucci, W. Willett, F. M. Sacks, C. H. Hennekens, and M. J. Stampfer
Lower Prostate Cancer Risk in Men with Elevated Plasma Lycopene Levels: Results of a Prospective Analysis
Cancer Res., March 1, 1999; 59(6): 1225 - 1230.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. B. Kritchevsky
beta -Carotene, Carotenoids and the Prevention of Coronary Heart Disease
J. Nutr., January 1, 1999; 129(1): 5 - 8.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by The American Society for Nutrition