American Journal of Clinical Nutrition, Vol 64, 952-959, Copyright © 1996 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Albumin kinetics in edematous and nonedematous protein-energy malnourished children

JF Morlese, T Forrester, A Badaloo, M Del Rosario, M Frazer and F Jahoor
US Department of Agriculture/Agricultural Research Service, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030-2600, USA.

The kinetic changes responsible for decreased plasma albumin and the relation between plasma albumin and the edema of protein-energy malnutrition (PEM) were investigated by measuring the plasma concentration, fractional (FSR) and intravascular absolute (ASR) synthesis rates of albumin in seven edematous and seven nonedematous children with PEM by using constant intragastric infusions of [2H3]leucine. Studies were done 2 d postadmission (study 1), 8 d postadmission (study 2), and at recovery (study 3). In study 1 there were no significant differences in plasma albumin concentrations in nonedematous and edematous children. In both groups, albumin concentrations but not FSRs were lower in studies 1 and 2 than in study 3. The ASR was lower only in edematous patients. These results suggest that repletion of the albumin pool of children with PEM is not mediated by changes in the FSR, and the edema of malnutrition is not solely due to hypoalbuminemia.

This article has been cited by other articles:

				C. H. van den Akker, F. W. te Braake, H. Schierbeek, T. Rietveld, D. J. Wattimena, J. E. H Bunt, and J. B van Goudoever Albumin synthesis in premature neonates is stimulated by parenterally administered amino acids during the first days of life Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1003 - 1008. [Abstract] [Full Text] [PDF]

				M. Reid, T. Forrester, A. Badaloo, W. C. Heird, and F. Jahoor Supplementation with Aromatic Amino Acids Improves Leucine Kinetics but Not Aromatic Amino Acid Kinetics in Infants with Infection, Severe Malnutrition, and Edema J. Nutr., November 1, 2004; 134(11): 3004 - 3010. [Abstract] [Full Text] [PDF]

				P. J. Reeds and P. J. Garlick Protein and Amino Acid Requirements and the Composition of Complementary Foods J. Nutr., September 1, 2003; 133(9): 2953S - 2961. [Abstract] [Full Text] [PDF]

				F. Jahoor, S. Abramson, and W. C Heird The protein metabolic response to HIV infection in young children Am. J. Clinical Nutrition, July 1, 2003; 78(1): 182 - 189. [Abstract] [Full Text] [PDF]

				O A F Bodamer and D Halliday Uses of stable isotopes in clinical diagnosis and research in the paediatric population Arch. Dis. Child., May 1, 2001; 84(5): 444 - 448. [Full Text]

				F. Jahoor, B. Gazzard, G. Phillips, D. Sharpstone, M. Delrosario, M. E. Frazer, W. Heird, R. Smith, and A. Jackson The acute-phase protein response to human immunodeficiency virus infection in human subjects Am J Physiol Endocrinol Metab, June 1, 1999; 276(6): E1092 - E1098. [Abstract] [Full Text] [PDF]

				F. Jahoor, L. Wykes, M. Del Rosario, M. Frazer, and P. J. Reeds Chronic Protein Undernutrition and an Acute Inflammatory Stimulus Elicit Different Protein Kinetic Responses in Plasma but Not in Muscle of Piglets J. Nutr., March 1, 1999; 129(3): 693 - 699. [Abstract] [Full Text]

				J. F. Morlese, T. Forrester, and F. Jahoor Acute-phase protein response to infection in severe malnutrition Am J Physiol Endocrinol Metab, July 1, 1998; 275(1): E112 - E117. [Abstract] [Full Text] [PDF]

				J. F. Morlese, T. Forrester, M. Del Rosario, M. Frazer, and F. Jahoor Repletion of the Plasma Pool of Nutrient Transport Proteins Occurs at Different Rates during the Nutritional Rehabilitation of Severely Malnourished Children J. Nutr., February 1, 1998; 128(2): 214 - 219. [Abstract] [Full Text]

				J. F. Morlese, T. Forrester, M. Del Rosario, M. Frazer, and F. Jahoor Transferrin Kinetics Are Altered in Children with Severe Protein-Energy Malnutrition J. Nutr., August 1, 1997; 127(8): 1469 - 1474. [Abstract] [Full Text]