| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 65, 121-127, Copyright © 1997 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
C Bonithon-Kopp, C Coudray, C Berr, PJ Touboul, JM Feve, A Favier and P Ducimetiere
INSERM U258, Paris, France.
There are few epidemiologic studies of the effects of lipid peroxidation and antioxidant status on atherosclerosis. The relation of lipid peroxidation evaluated by thiobarbituric acid-reactive substances (TBARS) and biological markers of antioxidant status to ultrasonographically assessed carotid atherosclerosis was examined from baseline data of a longitudinal study on cognitive and vascular aging (Etude sur le Vieillisement Arteriel, the EVA Study). The study sample was composed of 1187 mean and women aged 59-71 y without any history of coronary artery disease or stroke. Ultrasound examination included measurements of intima-media thickness (IMT) on the common carotid arteries (CCAs) and at the site of plaques. After adjustment for conventional cardiovascular risk factors, erythrocyte vitamin E was significantly and negatively associated with CCA-IMT in both men and women whereas plasma selenium and carotenoids were not. No association was found between TBARS and CCA-IMT in either sex. However, TBARS were significantly higher in men with carotid plaques than in those without. This association was strengthened in men with concentrations of erythrocyte vitamin E, plasma selenium, and carotenoids below the lowest quartile. Our findings give some epidemiologic support to the hypothesis that lipid peroxidation and low antioxidant status are involved in the early phases of atherosclerosis.
This article has been cited by other articles:
|
|
 |
|
  M. L. Bots, G. W. Evans, W. A. Riley, and D. E. Grobbee Carotid Intima-Media Thickness Measurements in Intervention Studies: Design Options, Progression Rates, and Sample Size Considerations: A Point of View Stroke, December 1, 2003; 34(12): 2985 - 2994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H Rissanen, S. Voutilainen, K. Nyyssonen, R. Salonen, G. A Kaplan, and J. T Salonen Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study Am. J. Clinical Nutrition, January 1, 2003; 77(1): 133 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Rissanen, S. Voutilainen, K. Nyyssonen, and J. T. Salonen Lycopene, Atherosclerosis, and Coronary Heart Disease Experimental Biology and Medicine, November 1, 2002; 227(10): 900 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Iannuzzi, E. Celentano, S. Panico, R. Galasso, G. Covetti, L. Sacchetti, F. Zarrilli, M. De Michele, and P. Rubba Dietary and circulating antioxidant vitamins in relation to carotid plaques in middle-aged women Am. J. Clinical Nutrition, September 1, 2002; 76(3): 582 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. McQuillan, J. Hung, J. P. Beilby, M. Nidorf, and P. L. Thompson Antioxidant vitamins and the risk of carotid atherosclerosis: The perth carotid ultrasound disease assessment study (CUDAS) J. Am. Coll. Cardiol., December 1, 2001; 38(7): 1788 - 1794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. RICCIARELLI, J.-M. ZINGG, and A. AZZI Vitamin E: protective role of a Janus molecule FASEB J, November 1, 2001; 15(13): 2314 - 2325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R Gale, H. E Ashurst, H. J Powers, and C. N Martyn Antioxidant vitamin status and carotid atherosclerosis in the elderly Am. J. Clinical Nutrition, September 1, 2001; 74(3): 402 - 408. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Klipstein-Grobusch, J. H. den Breeijen, D. E. Grobbee, H. Boeing, A. Hofman, and J. C. M. Witteman Dietary Antioxidants and Peripheral Arterial Disease : The Rotterdam Study Am. J. Epidemiol., July 15, 2001; 154(2): 145 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Meydani Vitamin E and Atherosclerosis: Beyond Prevention of LDL Oxidation J. Nutr., February 1, 2001; 131(2): 366S - 368. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Jang, J. H. Lee, E. Y. Cho, N. S. Chung, D. Topham, and B. Balderston Differences in body fat distribution and antioxidant status in Korean men with cardiovascular disease with or without diabetes Am. J. Clinical Nutrition, January 1, 2001; 73(1): 68 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Rissanen, S. Voutilainen, K. Nyyssonen, R. Salonen, and J. T. Salonen Low Plasma Lycopene Concentration Is Associated With Increased Intima-Media Thickness of the Carotid Artery Wall Arterioscler. Thromb. Vasc. Biol., December 1, 2000; 20(12): 2677 - 2681. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
