AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schaefer, E. J.
Right arrow Articles by Lichtenstein, A. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schaefer, E. J.
Right arrow Articles by Lichtenstein, A. H.
Agricola
Right arrow Articles by Schaefer, E. J.
Right arrow Articles by Lichtenstein, A. H.

American Journal of Clinical Nutrition, Vol 65, 823-830, Copyright © 1997 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Individual variability in lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets

EJ Schaefer, S Lamon-Fava, LM Ausman, JM Ordovas, BA Clevidence, JT Judd, BR Goldin, M Woods, S Gorbach and AH Lichtenstein
Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. SCHAEFER-LI@HNRC.TUFTS.EDU

The effects of National Cholesterol Education Program (NCEP) Step 2 diets on plasma lipoprotein profiles in 72 men [mean (+/- SD) age: 44 +/- 15 y, range: 19-81 y] and 48 women (mean age: 50 +/- 21 y, range: 21-78 y) participating in five previously published studies were examined. Subjects were placed on a baseline diet similar to an average American diet (35-41% total fat, 13-16% saturated fat, 31-45 mg cholesterol/MJ) and then on an NCEP Step 2 diet (18-29% total fat, 4-7% saturated fat, 11-20 mg cholesterol/MJ) under isoenergetic conditions. All food and drink were provided. Compared with the baseline diet, consumption of the NCEP Step 2 diets was associated with significant decreases in concentrations of low-density-lipoprotein (LDL) cholesterol (-18.9% and -15.6%, respectively) and high-density- lipoprotein (HDL) cholesterol (-17.0% and -11.2%, respectively) in both men and women. Men with the apolipoprotein (apo) E 3,4 phenotype had a significantly greater decrease in LDL cholesterol (-24.2%) with the NCEP Step 2 diets than men with the apo E 3,3 phenotype (-17.7%). Men with the apo A-IV 1,2 phenotype tended to have less LDL cholesterol lowering (-12.8%) than men with the apo A-IV 1,1 phenotype (-19.6%), but this difference was not significant. No differences were seen by apo E and A-IV phenotype in women. A large variability in lipid response to the diet was observed, with changes in LDL cholesterol ranging from +3% to -55% in men and and from +13% to -39% in women. Forty-eight percent of the variability in LDL-cholesterol response (in mmol/L) to the diet could be accounted for by baseline LDL concentrations and age in men, and 13% by age in women.


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
J. Tay, G. D. Brinkworth, M. Noakes, J. Keogh, and P. M. Clifton
Metabolic effects of weight loss on a very-low-carbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects.
J. Am. Coll. Cardiol., January 1, 2008; 51(1): 59 - 67.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. M Robinson, S. F Batelaan, H. E Syddall, A. A. Sayer, E. M Dennison, H. J Martin, D. J Barker, C. Cooper, and the Hertfordshire Cohort Study Group
Combined effects of dietary fat and birth weight on serum cholesterol concentrations: the Hertfordshire Cohort Study
Am. J. Clinical Nutrition, July 1, 2006; 84(1): 237 - 244.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
B. Fletcher, K. Berra, P. Ades, L. T. Braun, L. E. Burke, J. L. Durstine, J. M. Fair, G. F. Fletcher, D. Goff, L. L. Hayman, et al.
Managing Abnormal Blood Lipids: A Collaborative Approach
Circulation, November 15, 2005; 112(20): 3184 - 3209.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. Desroches, P Y. Chouinard, I. Galibois, L. Corneau, J. Delisle, B. Lamarche, P. Couture, and N. Bergeron
Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men
Am. J. Clinical Nutrition, August 1, 2005; 82(2): 309 - 319.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
C. D. Gardner, A. Coulston, L. Chatterjee, A. Rigby, G. Spiller, and J. W. Farquhar
The Effect of a Plant-Based Diet on Plasma Lipids in Hypercholesterolemic Adults: A Randomized Trial
Ann Intern Med, May 3, 2005; 142(9): 725 - 733.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
A.-M. Paradis, B. Fontaine-Bisson, Y. Bosse, J. Robitaille, S. Lemieux, H. Jacques, B. Lamarche, A. Tchernof, P. Couture, and M.-C. Vohl
The peroxisome proliferator-activated receptor {alpha} Leu162Val polymorphism influences the metabolic response to a dietary intervention altering fatty acid proportions in healthy men
Am. J. Clinical Nutrition, February 1, 2005; 81(2): 523 - 530.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
Y. Henkin and I. Shai
Dietary Treatment of Hypercholestrolemia: Can We Predict Long-Term Success?
J. Am. Coll. Nutr., December 1, 2003; 22(6): 555 - 561.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
Z. Li, J. D. Otvos, S. Lamon-Fava, W. V. Carrasco, A. H. Lichtenstein, J. R. McNamara, J. M. Ordovas, and E. J. Schaefer
Men and Women Differ in Lipoprotein Response to Dietary Saturated Fat and Cholesterol Restriction
J. Nutr., November 1, 2003; 133(11): 3428 - 3433.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
D. J. Jenkins, C. W. Kendall, A. Marchie, A. L Jenkins, L. S. Augustin, D. S Ludwig, N. D Barnard, and J. W Anderson
Type 2 diabetes and the vegetarian diet
Am. J. Clinical Nutrition, September 1, 2003; 78(3): 610S - 616.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
L. F Masson, G. McNeill, and A. Avenell
Genetic variation and the lipid response to dietary intervention: a systematic review
Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1098 - 1111.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
D. C. Nieman, D. W. Brock, D. Butterworth, A. C. Utter, and C. C. Nieman
Reducing Diet and/or Exercise Training Decreases the Lipid and Lipoprotein Risk Factors of Moderately Obese Women
J. Am. Coll. Nutr., August 1, 2002; 21(4): 344 - 350.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
A. H. Lichtenstein, L. M. Ausman, S. M. Jalbert, M. Vilella-Bach, M. Jauhiainen, S. McGladdery, A. T. Erkkila, C. Ehnholm, J. Frohlich, and E. J. Schaefer
Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects
J. Lipid Res., February 1, 2002; 43(2): 264 - 273.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
E. J Schaefer
Lipoproteins, nutrition, and heart disease
Am. J. Clinical Nutrition, February 1, 2002; 75(2): 191 - 212.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
Z. Sun, F. K Welty, G. G Dolnikowski, A. H Lichtenstein, and E. J Schaefer
Effects of a National Cholesterol Education Program Step II Diet on apolipoprotein A-IV metabolism within triacylglycerol-rich lipoproteins and plasma
Am. J. Clinical Nutrition, September 1, 2001; 74(3): 308 - 314.
[Abstract] [Full Text]

Home page
 Am. J. Clin. Nutr.Home page
E. Obarzanek, F. M Sacks, W. M Vollmer, G. A Bray, E. R Miller III, P.-H. Lin, N. M Karanja, M. M Most-Windhauser, T. J Moore, J. F Swain, et al.
Effects on blood lipids of a blood pressure-lowering diet: the Dietary Approaches to Stop Hypertension (DASH) Trial
Am. J. Clinical Nutrition, July 1, 2001; 74(1): 80 - 89.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
G. P. Bathalon, N. P. Hays, S. N. Meydani, B. Dawson-Hughes, E. J. Schaefer, R. Lipman, M. Nelson, A. S. Greenberg, and S. B. Roberts
Metabolic, Psychological, and Health Correlates of Dietary Restraint in Healthy Postmenopausal Women
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2001; 56(4): 206M - 211.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
R. M. Krauss
Atherogenic Lipoprotein Phenotype and Diet-Gene Interactions
J. Nutr., February 1, 2001; 131(2): 340S - 343.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
R. M. Krauss, R. H. Eckel, B. Howard, L. J. Appel, S. R. Daniels, R. J. Deckelbaum, J. W. Erdman Jr, P. Kris-Etherton, I. J. Goldberg, T. A. Kotchen, et al.
AHA Scientific Statement: AHA Dietary Guidelines: Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association
J. Nutr., January 1, 2001; 131(1): 132 - 146.
[Full Text]

Home page
 J. Lipid Res.Home page
R. B. Weinberg, B. W. Geissinger, K. Kasala, K. J. Hockey, J. G. Terry, L. Easter, and J. R. Crouse
Effect of apolipoprotein A-IV genotype and dietary fat on cholesterol absorption in humans
J. Lipid Res., December 1, 2000; 41(12): 2035 - 2041.
[Abstract] [Full Text]

Home page
 StrokeHome page
R. M. Krauss, R. H. Eckel, B. Howard, L. J. Appel, S. R. Daniels, R. J. Deckelbaum, J. W. Erdman Jr, P. Kris-Etherton, I. J. Goldberg, T. A. Kotchen, et al.
AHA Dietary Guidelines : Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association
Stroke, November 1, 2000; 31(11): 2751 - 2766.
[Full Text] [PDF]

Home page
 CirculationHome page
R. M. Krauss, R. H. Eckel, B. Howard, L. J. Appel, S. R. Daniels, R. J. Deckelbaum, J. W. Erdman Jr, P. Kris-Etherton, I. J. Goldberg, T. A. Kotchen, et al.
AHA Dietary Guidelines : Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association
Circulation, October 31, 2000; 102(18): 2284 - 2299.
[Full Text] [PDF]

Home page
 J. Lipid Res.Home page
R. M. Weggemans, P. L. Zock, S. Meyboom, H. Funke, and M. B. Katan
Apolipoprotein A4-1/2 polymorphism and response of serum lipids to dietary cholesterol in humans
J. Lipid Res., October 1, 2000; 41(10): 1623 - 1628.
[Abstract] [Full Text]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
A. P. Goldberg, M. J. Busby-Whitehead, L. I. Katzel, R. M. Krauss, M. Lumpkin, and J. M. Hagberg
Cardiovascular Fitness, Body Composition, and Lipoprotein Lipid Metabolism in Older Men
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2000; 55(6): 342M - 349.
[Abstract] [Full Text]

Home page
 Arch. Dis. Child.Home page
T Sveger, C-E Flodmark, K Nordborg, P Nilsson-Ehle, and N Borgfors
Hereditary dyslipidaemias and combined risk factors in children with a family history of premature coronary artery disease
Arch. Dis. Child., April 1, 2000; 82(4): 292 - 296.
[Abstract] [Full Text]

Home page
 Am. J. Clin. Nutr.Home page
R. M Krauss
Genetic recipes for heart-healthy diets
Am. J. Clinical Nutrition, March 1, 2000; 71(3): 668 - 669.
[Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
D. J. Jenkins, C. W. Kendall, and V. Vuksan
Viscous fibers, health claims, and strategies to reduce cardiovascular disease risk1
Am. J. Clinical Nutrition, February 1, 2000; 71(2): 401 - 402.
[Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
R. Nicolosi, S. J Bell, B. R Bistrian, I. Greenberg, R A. Forse, and G. L Blackburn
Plasma lipid changes after supplementation with {beta}-glucan fiber from yeast
Am. J. Clinical Nutrition, August 1, 1999; 70(2): 208 - 212.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
A. L. Romero, J. E. Romero, S. Galaviz, and M. L. Fernandez
Cookies Enriched with Psyllium or Oat Bran Lower Plasma LDL Cholesterol in Normal and Hypercholesterolemic Men from Northern Mexico
J. Am. Coll. Nutr., December 1, 1998; 17(6): 601 - 608.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
P. L. Elkin, B. A. Bauer, The Mayo Adherence Working Group, A. H. Lichtenstein, M. L. Stefanick, and P. D. Wood
Effects of Diet and Exercise on Cholesterol Levels
N. Engl. J. Med., November 19, 1998; 339(21): 1552 - 1553.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by The American Society for Nutrition