| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 65, 1774-1782, Copyright © 1997 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
A Aarsland, D Chinkes and RR Wolfe
Metabolism Unit, Shriners Burns Institute, Galveston, TX 77551, USA.
The magnitude of the capacity to convert carbohydrate to fat in the human body is still controversial, as is the extent to which it takes place in the liver as opposed to the adipose tissue. We calculated whole-body net fat synthesis from indirect calorimetry and substrate balance data from five healthy men in the basal state and after 1 and 4 d on a hyperenergetic carbohydrate diet (approximately 2.5 times energy expenditure). At the same time, the secretion of fatty acids synthesized in the liver was measured to determine the extent to which fat synthesis occurs in the liver in a lipogenic state. The respiratory exchange ratio (RER) was 0.81 +/- 0.01 in the basal state and 0.99 +/- 0.025 and 1.15 +/- 0.022 on days 1 and 4, respectively. Although there was net fat oxidation in the basal state (955 +/- 139 mg.kg-1.min-1), there was net fat synthesis at the whole-body level both during early (day 1; 481 +/- 205 mg.kg-1.min-1) and late (day 4; 2243 +/- 253 mg.kg- 1.min-1) carbohydrate overfeeding. Although hepatic secretion of fat synthesized de novo increased approximately 35-fold during the study (basal state, 1.0 +/- 0.3; day 1, 13.8 +/- 6.8; and day 4, 43.3 +/- 16.3 mg.kg-1.min-1) this could only account for a small portion of total fat synthesis. We conclude that the liver plays a quantitatively minor role when surplus carbohydrate energy is converted into fat in the human body. The main site for fat synthesis is likely to be the adipose tissue.
This article has been cited by other articles:
|
|
 |
|
  M. F-F Chong, L. Hodson, A. S Bickerton, R. Roberts, M. Neville, F. Karpe, K. N Frayn, and B. A Fielding Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding Am. J. Clinical Nutrition, April 1, 2008; 87(4): 817 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Cree and R. R. Wolfe Postburn trauma insulin resistance and fat metabolism Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E1 - E9. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.A. Paniagua, A. G. de la Sacristana, I. Romero, A. Vidal-Puig, J.M. Latre, E. Sanchez, P. Perez-Martinez, J. Lopez-Miranda, and F. Perez-Jimenez Monounsaturated Fat-Rich Diet Prevents Central Body Fat Distribution and Decreases Postprandial Adiponectin Expression Induced by a Carbohydrate-Rich Diet in Insulin-Resistant Subjects Diabetes Care, July 1, 2007; 30(7): 1717 - 1723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Sun, J. Bishop, S. Khalili, S. Vasdev, V. Gill, D. Pace, D. Fitzpatrick, E. Randell, Y.-G. Xie, and H. Zhang Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men Am. J. Clinical Nutrition, February 1, 2007; 85(2): 399 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Hall Computational model of in vivo human energy metabolism during semistarvation and refeeding Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E23 - E37. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Murphy Stable isotope methods for the in vivo measurement of lipogenesis and triglyceride metabolism J Anim Sci, April 1, 2006; 84(13_suppl): E94 - E. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-C. Lo, C.-H. Lin, and L.-J. Tsai Effects of Hypercaloric Feeding on Nutrition Status and Carbon Dioxide Production in Patients With Long-Term Mechanical Ventilation JPEN J Parenter Enteral Nutr, September 1, 2005; 29(5): 380 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. R. Bederman, T. Kasumov, A. E. Reszko, F. David, H. Brunengraber, and J. K. Kelleher In Vitro Modeling of Fatty Acid Synthesis under Conditions Simulating the Zonation of Lipogenic [13C]Acetyl-CoA Enrichment in the Liver J. Biol. Chem., October 8, 2004; 279(41): 43217 - 43226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Korach-Andre, H. Roth, D. Barnoud, M. Pean, F. Peronnet, and X. Leverve Glucose appearance in the peripheral circulation and liver glucose output in men after a large 13C starch meal Am. J. Clinical Nutrition, October 1, 2004; 80(4): 881 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, B. Jones Voy, S. Urs, S. Kim, M. Soltani-Bejnood, N. Quigley, Y.-R. Heo, M. Standridge, B. Andersen, M. Dhar, et al. The Human Fatty Acid Synthase Gene and De Novo Lipogenesis Are Coordinately Regulated in Human Adipose Tissue J. Nutr., May 1, 2004; 134(5): 1032 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Strawford, F. Antelo, M. Christiansen, and M. K. Hellerstein Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2H2O Am J Physiol Endocrinol Metab, April 1, 2004; 286(4): E577 - E588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Liu Intake of Refined Carbohydrates and Whole Grain Foods in Relation to Risk of Type 2 Diabetes Mellitus and Coronary Heart Disease J. Am. Coll. Nutr., August 1, 2002; 21(4): 298 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. ZAMMIT Insulin Stimulation of Hepatic Triacylglycerol Secretion in the Insulin-Replete State: Implications for the Etiology of Peripheral Insulin Resistance Ann. N.Y. Acad. Sci., June 1, 2002; 967(1): 52 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. KUNESOVA, S. PHINNEY, V. HAINER, E. TVRZICKA, V. STICH, J. PARIZKOVA, A. ZAK, and A. STUNKARD The Responses of Serum and Adipose Fatty Acids to a One-Year Weight Reduction Regimen in Female Obese Monozygotic Twins Ann. N.Y. Acad. Sci., June 1, 2002; 967(1): 311 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Hardin, A. Leblanc, G. Marshall, and D. K. Seilheimer Mechanisms of insulin resistance in cystic fibrosis Am J Physiol Endocrinol Metab, November 1, 2001; 281(5): E1022 - E1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Zammit, I. J. Waterman, D. Topping, and G. McKay Insulin Stimulation of Hepatic Triacylglycerol Secretion and the Etiology of Insulin Resistance J. Nutr., August 1, 2001; 131(8): 2074 - 2077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Jéquier Is Fat Intake a Risk Factor for Fat Gain in Children? J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 980 - 983. [Full Text]
|
|
|
|
|
|
J.-M. Schwarz, R. Chiolero, J.-P. Revelly, C. Cayeux, P. Schneiter, E. Jequier, T. Chen, and L. Tappy Effects of enteral carbohydrates on de novo lipogenesis in critically ill patients Am. J. Clinical Nutrition, October 1, 2000; 72(4): 940 - 945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Z. Martini, O. Irtun, D. L. Chinkes, R. E. Barrow, and R. R. Wolfe Glucose effects on lung surfactant kinetics in conscious pigs Am J Physiol Endocrinol Metab, October 1, 2000; 279(4): E920 - E926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Xue and M. B. Zemel Relationship between Human Adipose Tissue Agouti and Fatty Acid Synthase (FAS) J. Nutr., October 1, 2000; 130(10): 2478 - 2481. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. Jequier and L. Tappy Regulation of Body Weight in Humans Physiol Rev, April 1, 1999; 79(2): 451 - 480. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
