| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 66, 460S-463S, Copyright © 1997 by The American Society for Clinical Nutrition, Inc
REVIEW ARTICLES |
RK Chandra
Department of Pediatrics, Memorial University of Newfoundland, Canada.
Nutrition is a critical determinant of immune responses and malnutrition the most common cause of immunodeficiency worldwide. Protein-energy malnutrition is associated with a significant impairment of cell-mediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations, and cytokine production. Deficiency of single nutrients also results in altered immune responses: this is observed even when the deficiency state is relatively mild. Of the micronutrients, zinc; selenium; iron; copper; vitamins A, C, E, and B-6; and folic acid have important influences on immune responses. Overnutrition and obesity also reduce immunity. Low- birth-weight infants have a prolonged impairment of cell-mediated immunity that can be partly restored by providing extra amounts of dietary zinc. In the elderly, impaired immunity can be enhanced by modest amounts of a combination of micronutrients. These findings have considerable practical and public health significance.
This article has been cited by other articles:
|
|
 |
|
  C. W. Wieland, S. Florquin, E. D. Chan, J. C. Leemans, S. Weijer, A. Verbon, G. Fantuzzi, and T. van der Poll Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice Int. Immunol., November 1, 2005; 17(11): 1399 - 1408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. MacInnis, D. R. English, J. L. Hopper, and G. G. Giles Body Size and Composition and the Risk of Lymphohematopoietic Malignancies J Natl Cancer Inst, August 3, 2005; 97(15): 1154 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Villena, S. Racedo, G. Aguero, E. Bru, M. Medina, and S. Alvarez Lactobacillus casei Improves Resistance to Pneumococcal Respiratory Infection in Malnourished Mice J. Nutr., June 1, 2005; 135(6): 1462 - 1469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. P. Plackett, E. D. Boehmer, D. E. Faunce, and E. J. Kovacs Aging and innate immune cells J. Leukoc. Biol., August 1, 2004; 76(2): 291 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Baez-Saldana and E. Ortega Biotin Deficiency Blocks Thymocyte Maturation, Accelerates Thymus Involution, and Decreases Nose-Rump Length in Mice J. Nutr., August 1, 2004; 134(8): 1970 - 1977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Pan, K. C. Johnson, A.-M. Ugnat, S. W. Wen, and Y. Mao Association of Obesity and Cancer Risk in Canada Am. J. Epidemiol., February 1, 2004; 159(3): 259 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Boehmer, J. Goral, D. E. Faunce, and E. J. Kovacs Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression J. Leukoc. Biol., February 1, 2004; 75(2): 342 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Sharkey Risk and Presence of Food Insufficiency Are Associated with Low Nutrient Intakes and Multimorbidity among Homebound Older Women Who Receive Home-Delivered Meals J. Nutr., November 1, 2003; 133(11): 3485 - 3491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Briet, C. Twomey, and K. N Jeejeebhoy Effect of malnutrition and short-term refeeding on peripheral blood mononuclear cell mitochondrial complex I activity in humans Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1304 - 1311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Barringer, J. K. Kirk, A. C. Santaniello, K. L. Foley, and R. Michielutte Effect of a Multivitamin and Mineral Supplement on Infection and Quality of Life: A Randomized, Double-Blind, Placebo-Controlled Trial Ann Intern Med, March 4, 2003; 138(5): 365 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H Siekmann, L. H Allen, M. R Watnik, P. Nestel, C. G Neumann, Y. Shoenfeld, J. B Peter, M. Patnik, A. A Ansari, R. L Coppel, et al. Titers of antibody to common pathogens: relation to food-based interventions in rural Kenyan schoolchildren Am. J. Clinical Nutrition, January 1, 2003; 77(1): 242 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Papet, B. Ruot, D. Breuille, S. Walrand, M.-C. Farges, M.-P. Vasson, and C. Obled Bacterial Infection Affects Protein Synthesis in Primary Lymphoid Tissues and Circulating Lymphocytes of Rats J. Nutr., July 1, 2002; 132(7): 2028 - 2032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gambling, Z. Charania, L. Hannah, C. Antipatis, R. G. Lea, and H. J. McArdle Effect of Iron Deficiency on Placental Cytokine Expression and Fetal Growth in the Pregnant Rat Biol Reprod, February 1, 2002; 66(2): 516 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. De Schoenmakere, R. Vanholder, S. Rottey, P. Duym, and N. Lameire Relationship between gastric emptying and clinical and biochemical factors in chronic haemodialysis patients Nephrol. Dial. Transplant., September 1, 2001; 16(9): 1850 - 1855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. S. Rogers, P. M. Emmett, and the ALSPAC Study Team Fat Content of the Diet Among Preschool Children in Southwest Britain: II. Relationship With Growth, Blood Lipids, and Iron Status Pediatrics, September 1, 2001; 108(3): e49 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Shahar, R. Schultz, A. Shahar, and R. R. Wing The Effect of Widowhood on Weight Change, Dietary Intake, and Eating Behavior in the Elderly Population J Aging Health, May 1, 2001; 13(2): 186 - 199. [Abstract] [PDF]
|
|
|
|
|
|
S. Walrand, C. Chambon-Savanovitch, C. Felgines, J. Chassagne, F. Raul, B. Normand, M.-C. Farges, B. Beaufrere, M.-P. Vasson, and L. Cynober Aging: a barrier to renutrition? Nutritional and immunologic evidence in rats Am. J. Clinical Nutrition, September 1, 2000; 72(3): 816 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Baum, G. Shor-Posner, and A. Campa Zinc Status in Human Immunodeficiency Virus Infection J. Nutr., May 1, 2000; 130(5): 1421S - 1423. [Abstract] [Full Text]
|
|
|
|
|
|
J. B. Campbell, J. W. Busse, and H. S. Injeyan Chiropractors and Vaccination: A Historical Perspective Pediatrics, April 1, 2000; 105(4): 43e - 43. [Abstract] [Full Text]
|
|
|
|
 |
|
 I. Dahlen, E. Lindberg, C. Janson, and G. Stalenheim Delayed Type of Hypersensitivity and Late Allergic Reactions in Patients with Stable COPD* Chest, December 1, 1999; 116(6): 1625 - 1631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nagata, W. Tobitani, N. Kiriike, T. Iketani, and S. Yamagami Capacity to Produce Cytokines During Weight Restoration in Patients With Anorexia Nervosa Psychosom Med, May 1, 1999; 61(3): 371 - 377. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
