| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 66, 911-916, Copyright © 1997 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
PF Jacques, A Taylor, SE Hankinson, WC Willett, B Mahnken, Y Lee, K Vaid and M Lahav
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
We designed the present study to examine the cross-sectional relation between age-related lens opacities and vitamin C supplement use over a 10-12-y period before assessment of lens status in women without diagnosed cataract or diabetes. This design avoids biased measurement of nutrient intake that results when knowledge of lens opacities influences nutrition-related behavior or its reporting. The participants were 247 Boston-area women aged 56-71 y selected from the Nurses' Health Study cohort with oversampling of women with high or low vitamin C intakes. Lens opacities were graded with the Lens Opacification Classification System II. Use of vitamin C supplements for > or = 10 y (n = 26) was associated with a 77% lower prevalence of early lens opacities (odds ratio: 0.23; 95% CI: 0.09, 0.60) at any lens site and a 83% lower prevalence of moderate lens opacities (odds ratio: 0.17; 95% CI: 0.03, 0.85) at any lens site compared with women who did not use vitamin C supplements (n = 141) after adjustment for age and other potentially confounding variables. Women who consumed vitamin C supplements for < 10 y showed no evidence of a reduced prevalence of early opacities. These data, together with data from earlier experimental and epidemiologic studies, suggest that long-term consumption of vitamin C supplements may substantially reduce the development of age-related lens opacities.
This article has been cited by other articles:
|
|
 |
|
  X. Fan, L. W. Reneker, M. E. Obrenovich, C. Strauch, R. Cheng, S. M. Jarvis, B. J. Ortwerth, and V. M. Monnier Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model PNAS, November 7, 2006; 103(45): 16912 - 16917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D C Gritz, M Srinivasan, S D Smith, U Kim, T M Lietman, J H Wilkins, B Priyadharshini, R K John, S Aravind, N V Prajna, et al. The Antioxidants in Prevention of Cataracts Study: effects of antioxidant supplements on cataract progression in South India Br. J. Ophthalmol., July 1, 2006; 90(7): 847 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Q Pham and R. Plakogiannis Vitamin E Supplementation in Alzheimer's Disease, Parkinson's Disease, Tardive Dyskinesia, and Cataract: Part 2 Ann. Pharmacother., December 1, 2005; 39(12): 2065 - 2071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-J. Chiu, M. S Morris, G. Rogers, P. F Jacques, L. T Chylack Jr, W. Tung, S. E Hankinson, W. C Willett, and A. Taylor Carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacities Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1411 - 1416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. F. Jacques, A. Taylor, S. Moeller, S. E. Hankinson, G. Rogers, W. Tung, J. Ludovico, W. C. Willett, and L. T. Chylack Jr Long-term Nutrient Intake and 5-Year Change in Nuclear Lens Opacities Arch Ophthalmol, April 1, 2005; 123(4): 517 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Moeller, A. Taylor, K. L. Tucker, M. L. McCullough, L. T. Chylack Jr, S. E. Hankinson, W. C. Willett, and P. F. Jacques Overall Adherence to the Dietary Guidelines for Americans Is Associated with Reduced Prevalence of Early Age-Related Nuclear Lens Opacities in Women J. Nutr., July 1, 2004; 134(7): 1812 - 1819. [Abstract] [Full Text]
|
|
|
|
|
|
T. T. J. M. Berendschot, W. M. R. Broekmans, I. A. A. Klopping-Ketelaars, A. F. M. Kardinaal, G. van Poppel, and D. van Norren Lens Aging in Relation to Nutritional Determinants and Possible Risk Factors for Age-Related Cataract Arch Ophthalmol, December 1, 2002; 120(12): 1732 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Younan, P. Mitchell, R. G. Cumming, J. Panchapakesan, E. Rochtchina, and A. M. Hales Hormone Replacement Therapy, Reproductive Factors, and the Incidence of Cataract and Cataract Surgery: : The Blue Mountains Eye Study Am. J. Epidemiol., June 1, 2002; 155(11): 997 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Taylor, P. F Jacques, L. T Chylack Jr, S. E Hankinson, P. M Khu, G. Rogers, J. Friend, W. Tung, J. K Wolfe, N. Padhye, et al. Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities Am. J. Clinical Nutrition, March 1, 2002; 75(3): 540 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. Jacques, L. T. Chylack Jr, S. E. Hankinson, P. M. Khu, G. Rogers, J. Friend, W. Tung, J. K. Wolfe, N. Padhye, W. C. Willett, et al. Long-term Nutrient Intake and Early Age-Related Nuclear Lens Opacities Arch Ophthalmol, July 1, 2001; 119(7): 1009 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Mares-Perlman, B. J. Lyle, R. Klein, A. I. Fisher, W. E. Brady, G. M. VandenLangenberg, J. N. Trabulsi, and M. Palta Vitamin Supplement Use and Incident Cataracts in a Population-Based Study Arch Ophthalmol, November 1, 2000; 118(11): 1556 - 1563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C Carr and B. Frei Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans Am. J. Clinical Nutrition, June 1, 1999; 69(6): 1086 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Levine, S. C. Rumsey, R. Daruwala, J. B. Park, and Y. Wang Criteria and Recommendations for Vitamin C Intake JAMA, April 21, 1999; 281(15): 1415 - 1423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. N. AMES Micronutrient Deficiencies: A Major Cause of DNA Damage Ann. N.Y. Acad. Sci., January 1, 1999; 889(1): 87 - 106. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
