| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 66, 1072-1085, Copyright © 1997 by The American Society for Clinical Nutrition, Inc
REVIEW ARTICLES |
ME Daly, C Vale, M Walker, KG Alberti and JC Mathers
Department of Biological and Nutritional Sciences, Human Diabetes, University of Newcastle upon Tyne, United Kingdom. m.e.daly@newcastle.ac.uk
Insulin resistance is associated with diabetes mellitus, ischemic heart disease, and hypertension both independently and as part of syndrome X. Environmental influences on SI are incompletely understood. Exercise has a strong beneficial effect and obesity a strong adverse effect. The balance of evidence suggests that a high-fat diet is likely to reduce insulin sensitivity but the effects of dietary carbohydrates are more controversial. Extensive studies in animals showed a detrimental effect of diets very high in fructose or sucrose, particularly in association with induction of hypertriglyceridemia. The more limited studies in humans had conflicting results, partly because of heterogeneity of design. Certain groups of subjects may be more sensitive to adverse effects of high intakes of dietary sucrose or fructose. More carefully controlled studies in humans are needed to provide evidence on which to base public health policies with respect to dietary carbohydrates and SI.
This article has been cited by other articles:
|
|
 |
|
  A. E. Cust, N. Slimani, R. Kaaks, M. van Bakel, C. Biessy, P. Ferrari, M. Laville, A. Tjonneland, A. Olsen, K. Overvad, et al. Dietary Carbohydrates, Glycemic Index, Glycemic Load, and Endometrial Cancer Risk within the European Prospective Investigation into Cancer and Nutrition Cohort Am. J. Epidemiol., October 15, 2007; 166(8): 912 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. A. Black, M. Spence, R. O. McMahon, G. J. Cuskelly, C. N. Ennis, D. R. McCance, I. S. Young, P. M. Bell, and S. J. Hunter Effect of Eucaloric High- and Low-Sucrose Diets With Identical Macronutrient Profile on Insulin Resistance and Vascular Risk: A Randomized Controlled Trial Diabetes, December 1, 2006; 55(12): 3566 - 3572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Mizoue, T. Yamaji, S. Tabata, K. Yamaguchi, S. Ogawa, M. Mineshita, and S. Kono Dietary Patterns and Glucose Tolerance Abnormalities in Japanese Men J. Nutr., May 1, 2006; 136(5): 1352 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Freire, M. A. Cardoso, S. G.A. Gimeno, S. R.G. Ferreira, and for the Japanese-Brazilian Diabetes Study Group Dietary Fat Is Associated With Metabolic Syndrome in Japanese Brazilians Diabetes Care, July 1, 2005; 28(7): 1779 - 1785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Kushner Low-Carbohydrate Diets, Con: The Mythical Phoenix or Credible Science? Nutr Clin Pract, February 1, 2005; 20(1): 13 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Carnethon, C. M. Loria, J. O. Hill, S. Sidney, P. J. Savage, and K. Liu Risk Factors for the Metabolic Syndrome: The Coronary Artery Risk Development in Young Adults (CARDIA) study, 1985-2001 Diabetes Care, November 1, 2004; 27(11): 2707 - 2715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Borugian, S. B. Sheps, C. Kim-Sing, C. Van Patten, J. D. Potter, B. Dunn, R. P. Gallagher, and T. G. Hislop Insulin, Macronutrient Intake, and Physical Activity: Are Potential Indicators of Insulin Resistance Associated with Mortality from Breast Cancer? Cancer Epidemiol. Biomarkers Prev., July 1, 2004; 13(7): 1163 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsuzaka, H. Shimano, N. Yahagi, M. Amemiya-Kudo, H. Okazaki, Y. Tamura, Y. Iizuka, K. Ohashi, S. Tomita, M. Sekiya, et al. Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice Diabetes, March 1, 2004; 53(3): 560 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wei, M. E. Bizeau, and M. J. Pagliassotti An Acute Increase in Fructose Concentration Increases Hepatic Glucose-6-Phosphatase mRNA via Mechanisms That Are Independent of Glycogen Synthase Kinase-3 in Rats J. Nutr., March 1, 2004; 134(3): 545 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. McKeown, J. B. Meigs, S. Liu, E. Saltzman, P. W.F. Wilson, and P. F. Jacques Carbohydrate Nutrition, Insulin Resistance, and the Prevalence of the Metabolic Syndrome in the Framingham Offspring Cohort Diabetes Care, February 1, 2004; 27(2): 538 - 546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Daly Sugars, insulin sensitivity, and the postprandial state Am. J. Clinical Nutrition, October 1, 2003; 78(4): 865S - 872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Brand-Miller, M. Thomas, V. Swan, Z. I. Ahmad, P. Petocz, and S. Colagiuri Physiological Validation of the Concept of Glycemic Load in Lean Young Adults J. Nutr., September 1, 2003; 133(9): 2728 - 2732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Yang, J. M Kerver, Y. K. Park, J. Kayitsinga, D. B Allison, and W. O Song Carbohydrate intake and biomarkers of glycemic control among US adults: the third National Health and Nutrition Examination Survey (NHANES III) Am. J. Clinical Nutrition, June 1, 2003; 77(6): 1426 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Donmoyer, D. B. Lacy, Y. Zhang, S.-S. Chen, and O. P. McGuinness Impact of chronic fructose infusion on hepatic metabolism during TPN administration Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1151 - E1158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Cordain, S. Lindeberg, M. Hurtado, K. Hill, S. B. Eaton, and J. Brand-Miller Acne Vulgaris: A Disease of Western Civilization Arch Dermatol, December 1, 2002; 138(12): 1584 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S Elliott, N. L Keim, J. S Stern, K. Teff, and P. J Havel Fructose, weight gain, and the insulin resistance syndrome Am. J. Clinical Nutrition, November 1, 2002; 76(5): 911 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Sunehag, G. Toffolo, M. S. Treuth, N. F. Butte, C. Cobelli, D. M. Bier, and M. W. Haymond Effects of Dietary Macronutrient Content on Glucose Metabolism in Children J. Clin. Endocrinol. Metab., November 1, 2002; 87(11): 5168 - 5178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Busserolles, A. Mazur, E. Gueux, E. Rock, and Y. Rayssiguier Metabolic Syndrome in the Rat: Females Are Protected Against the Pro-Oxidant Effect of a High Sucrose Diet Experimental Biology and Medicine, October 1, 2002; 227(9): 837 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Arslanian, R. Saad, V. Lewy, K. Danadian, and J. Janosky Hyperinsulinemia in African-American Children: Decreased Insulin Clearance and Increased Insulin Secretion and Its Relationship to Insulin Sensitivity Diabetes, October 1, 2002; 51(10): 3014 - 3019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Michaud, S. Liu, E. Giovannucci, W. C. Willett, G. A. Colditz, and C. S. Fuchs Dietary Sugar, Glycemic Load, and Pancreatic Cancer Risk in a Prospective Study J Natl Cancer Inst, September 4, 2002; 94(17): 1293 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Commerford, J. B. Ferniza, M. E. Bizeau, J. S. Thresher, W. T. Willis, and M. J. Pagliassotti Diets enriched in sucrose or fat increase gluconeogenesis and G-6-Pase but not basal glucose production in rats Am J Physiol Endocrinol Metab, September 1, 2002; 283(3): E545 - E555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Willett, J. Manson, and S. Liu Glycemic index, glycemic load, and risk of type 2 diabetes Am. J. Clinical Nutrition, July 1, 2002; 76(1): 274S - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F X. Pi-Sunyer Glycemic index and disease Am. J. Clinical Nutrition, July 1, 2002; 76(1): 290S - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Davies, D. J. Baer, J. T. Judd, E. D. Brown, W. S. Campbell, and P. R. Taylor Effects of Moderate Alcohol Intake on Fasting Insulin and Glucose Concentrations and Insulin Sensitivity in Postmenopausal Women: A Randomized Controlled Trial JAMA, May 15, 2002; 287(19): 2559 - 2562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Borugian, S. B. Sheps, A. S. Whittemore, A. H. Wu, J. D. Potter, and R. P. Gallagher Carbohydrates and Colorectal Cancer Risk among Chinese in North America Cancer Epidemiol. Biomarkers Prev., February 1, 2002; 11(2): 187 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Giovannucci Insulin, Insulin-Like Growth Factors and Colon Cancer: A Review of the Evidence J. Nutr., November 1, 2001; 131(11): 3109S - 3120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Bessesen The Role of Carbohydrates in Insulin Resistance J. Nutr., October 1, 2001; 131(10): 2782S - 2786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vidon, P. Boucher, A. Cachefo, O. Peroni, F. Diraison, and M. Beylot Effects of isoenergetic high-carbohydrate compared with high-fat diets on human cholesterol synthesis and expression of key regulatory genes of cholesterol metabolism Am. J. Clinical Nutrition, May 1, 2001; 73(5): 878 - 884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Donmoyer, J. Ejiofor, D. B. Lacy, S.-S. Chen, and O. P. McGuinness Fructose augments infection-impaired net hepatic glucose uptake during TPN administration Am J Physiol Endocrinol Metab, May 1, 2001; 280(5): E703 - E711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Raben, J. J Holst, J. Madsen, and A. Astrup Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women Am. J. Clinical Nutrition, February 1, 2001; 73(2): 177 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dirlewanger, P. Schneiter, E. Jequier, and L. Tappy Effects of fructose on hepatic glucose metabolism in humans Am J Physiol Endocrinol Metab, October 1, 2000; 279(4): E907 - E911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E Daly, C. Vale, M. Walker, A. Littlefield, K George, M. Alberti, and J. Mathers Acute fuel selection in response to high-sucrose and high-starch meals in healthy men Am. J. Clinical Nutrition, June 1, 2000; 71(6): 1516 - 1524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Hudgins, M. K. Hellerstein, C. E. Seidman, R. A. Neese, J. D. Tremaroli, and J. Hirsch Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects J. Lipid Res., April 1, 2000; 41(4): 595 - 604. [Abstract] [Full Text]
|
|
|
|
|
|
E. J Parks and M. K Hellerstein Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms1 Am. J. Clinical Nutrition, February 1, 2000; 71(2): 412 - 433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Ludwig, M. A. Pereira, C. H. Kroenke, J. E. Hilner, L. Van Horn, M. L. Slattery, and D. R. Jacobs Jr Dietary Fiber, Weight Gain, and Cardiovascular Disease Risk Factors in Young Adults JAMA, October 27, 1999; 282(16): 1539 - 1546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Baschetti, J. C Mathers, and M. E Daly High-sucrose diets and insulin sensitivity Am. J. Clinical Nutrition, March 1, 1999; 69(3): 575 - 576. [Full Text]
|
|
|
|
|
|
G. Misciagna, S. Centonze, C. Leoci, V. Guerra, A. M. Cisternino, R. Ceo, and M. Trevisan Diet, physical activity, and gallstones—a population-based, case-control study in southern Italy Am. J. Clinical Nutrition, January 1, 1999; 69(1): 120 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nagai, Y. Nishio, T. Nakamura, H. Maegawa, R. Kikkawa, and A. Kashiwagi Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha Am J Physiol Endocrinol Metab, May 1, 2002; 282(5): E1180 - E1190. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
