AJCN Cancer Health Disparities Conference
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alles, M. S.
Right arrow Articles by Nagengast, F. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alles, M. S.
Right arrow Articles by Nagengast, F. M.
Agricola
Right arrow Articles by Alles, M. S.
Right arrow Articles by Nagengast, F. M.

American Journal of Clinical Nutrition, Vol 66, 1286-1292, Copyright © 1997 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Bacterial fermentation of fructooligosaccharides and resistant starch in patients with an ileal pouch-anal anastomosis

MS Alles, MB Katan, JM Salemans, KM Van Laere, MJ Gerichhausen, MJ Rozendaal and FM Nagengast
Department of Human Nutrition, Wageningen Agricultural University, Netherlands. martine.alles@staff.nuepi.wau.nl

Patients with large bowel disease may undergo ileal pouch-anal anastomosis, in which the colon is removed and part of the distal ileum is used to construct a pelvic reservoir. Competence of the ileal pouch to ferment carbohydrates is associated with the absence of pouchitis. However, the extent to which bacterial fermentation takes place and whether it is affected by diet are unclear. We investigated fermentation of two nondigestible carbohydrates, fructooligosaccharides and resistant starch, in 15 healthy patients with an ileal pouch by using a placebo-controlled crossover design (with glucose as the placebo). Apparent fermentability of fructooligosaccharides was 83%; that of resistant starch was 46%. Resistant starch increased fecal excretion of butyrate by 69% whereas fructooligosaccharides reduced excretion of amino acid-derived isobutyrate by 94% and of isovalerate by 77%. Fructooligosaccharides also significantly increased fecal weight (651 compared with 541 g/d) and breath-hydrogen excretion (286 compared with 85 ppm x h). Bacterial fermentation of nondigestible carbohydrates in pouches takes place to an appreciable extent and in a substrate-specific manner. The relation between such fermentation and inflammation of the pouch (pouchitis) deserves study.


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
K. E Scholz-Ahrens, G. Schaafsma, E. G. van den Heuvel, and J. Schrezenmeir
Effects of prebiotics on mineral metabolism
Am. J. Clinical Nutrition, February 1, 2001; 73(2): 459S - 464.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. S Alles, R. Hartemink, S. Meyboom, J. L Harryvan, K. M. Van Laere, F. M Nagengast, and J. G. Hautvast
Effect of transgalactooligosaccharides on the composition of the human intestinal microflora and on putative risk markers for colon cancer
Am. J. Clinical Nutrition, May 1, 1999; 69(5): 980 - 991.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. S Alles, N. M de Roos, J C. Bakx, E. van de Lisdonk, P. L Zock, and J. G. Hautvast
Consumption of fructooligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes
Am. J. Clinical Nutrition, January 1, 1999; 69(1): 64 - 69.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by The American Society for Nutrition