| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 67, 143-147, Copyright © 1998 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
JP Allard, E Aghdassi, J Chau, I Salit and S Walmsley
Department of Medicine, University of Toronto, Ontario, Canada. johane.allard@utoronto.ca
Increased lipid peroxidation induced by reactive oxygen species may play a role in the stimulation of HIV replication. In this study we compared lipid peroxidation indexes and plasma antioxidant micronutrients between 49 nonsmoking HIV-positive patients with no active opportunistic infection (25 asymptomatic and 24 with AIDS) and 15 age-matched seronegative control subjects. Breath-alkane output, plasma lipid peroxides, antioxidant vitamins, and trace elements were measured. Vitamin C (40.7 +/- 3.02 compared with 75.7 +/- 4.3 mumol/L, P < 0.005), alpha-tocopherol (22.52 +/- 1.18 compared with 26.61 +/- 2.60 mumol/L, P < 0.05), beta-carotene (0.23 +/- 0.04 compared with 0.38 +/- 0.04 mumol/L, P < 0.05), and selenium (0.37 +/- 0.05 compared with 0.85 +/- 0.09 mumol/L, P < 0.005) concentrations were significantly lower in the HIV-positive patients. Lipid peroxides (50.7 +/- 8.2 compared with 4.5 +/- 0.8 mumol/L, P < 0.005), breath pentane (9.05 +/- 1.23 compared with 6.06 +/- 0.56 pmol.kg-1.min-1, P < 0.05), and ethane output (28.1 +/- 3.41 compared with 11.42 +/- 0.55 pmol.kg- 1.min-1, P < 0.05) were significantly higher in the HIV-positive patients. These results showed an increase in oxidative stress and a weakened antioxidant defense system in HIV-positive patients. Whether supplementation of antioxidant vitamins will reduce this oxidative stress is still unknown.
This article has been cited by other articles:
|
|
 |
|
  P. K Drain, R. Kupka, F. Mugusi, and W. W Fawzi Micronutrients in HIV-positive persons receiving highly active antiretroviral therapy Am. J. Clinical Nutrition, February 1, 2007; 85(2): 333 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C Papathakis, N. C Rollins, C. J Chantry, M. L Bennish, and K. H Brown Micronutrient status during lactation in HIV-infected and HIV-uninfected South African women during the first 6 mo after delivery Am. J. Clinical Nutrition, January 1, 2007; 85(1): 182 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Oosthuizen, A. van Graan, A. Kruger, and H. H Vorster Polyunsaturated fatty acid intake is adversely related to liver function in HIV-infected subjects: the THUSA study Am. J. Clinical Nutrition, May 1, 2006; 83(5): 1193 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B Stephensen, G. S Marquis, R. A Jacob, L. A Kruzich, S. D Douglas, and C. M Wilson Vitamins C and E in adolescents and young adults with HIV infection. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 870 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Engels, M. V. Brock, J. Chen, C. M. Hooker, M. Gillison, and R. D. Moore Elevated Incidence of Lung Cancer Among HIV-Infected Individuals J. Clin. Oncol., March 20, 2006; 24(9): 1383 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Aghdassi, I. E. Salit, L. Fung, L. Sreetharan, S. Walmsley, and J. P. Allard Is Chromium an Important Element in HIV-Positive Patients with Metabolic Abnormalities? An Hypothesis Generating Pilot Study. J. Am. Coll. Nutr., February 1, 2006; 25(1): 56 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Cole, B. Langkamp-Henken, B. S. Bender, K. Findley, K. A. Herrlinger-Garcia, and C. R. Uphold Oxidative Stress and Antioxidant Capacity in Smoking and Nonsmoking Men With HIV/Acquired Immunodeficiency Syndrome Nutr Clin Pract, December 1, 2005; 20(6): 662 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kupka, G. I. Msamanga, D. Spiegelman, S. Morris, F. Mugusi, D. J. Hunter, and W. W. Fawzi Selenium Status Is Associated with Accelerated HIV Disease Progression among HIV-1-Infected Pregnant Women in Tanzania J. Nutr., October 1, 2004; 134(10): 2556 - 2560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Crimi, A. Liguori, M. Condorelli, M. Cioffi, M. Astuto, P. Bontempo, O. Pignalosa, M. T. Vietri, A. M. Molinari, V. Sica, et al. The Beneficial Effects of Antioxidant Supplementation in Enteral Feeding in Critically Ill Patients: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial Anesth. Analg., September 1, 2004; 99(3): 857 - 863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Geiben-Lynn, M. Kursar, N. V. Brown, M. M. Addo, H. Shau, J. Lieberman, A. D. Luster, and B. D. Walker HIV-1 Antiviral Activity of Recombinant Natural Killer Cell Enhancing Factors, NKEF-A and NKEF-B, Members of the Peroxiredoxin Family J. Biol. Chem., January 10, 2003; 278(3): 1569 - 1574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Goodyear-Bruch and J. D. Pierce Oxidative Stress in Critically Ill Patients Am. J. Crit. Care., November 1, 2002; 11(6): 543 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E Wendland, E. Aghdassi, C. Tam, J. Carrrier, A H. Steinhart, S. L Wolman, D. Baron, and J. P Allard Lipid peroxidation and plasma antioxidant micronutrients in Crohn disease Am. J. Clinical Nutrition, August 1, 2001; 74(2): 259 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Friis, E. Gomo, P. Kastel, P. Ndhlovu, N. Nyazema, H. Krarup, and K. F. Michaelsen HIV and other predictors of serum {beta}-carotene and retinol in pregnancy: a cross-sectional study in Zimbabwe Am. J. Clinical Nutrition, June 1, 2001; 73(6): 1058 - 1065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jang, J. H. Lee, E. Y. Cho, N. S. Chung, D. Topham, and B. Balderston Differences in body fat distribution and antioxidant status in Korean men with cardiovascular disease with or without diabetes Am. J. Clinical Nutrition, January 1, 2001; 73(1): 68 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zhao, A. G. Cox, J. A. Ruzicka, A. A. Bhat, W. Zhang, and E. W. Taylor Molecular modeling and in vitro activity of an HIV-1-encoded glutathione peroxidase PNAS, June 6, 2000; 97(12): 6356 - 6361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J Lenton, H. Therriault, A. M Cantin, T. Fulop, H. Payette, and J R. Wagner Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes Am. J. Clinical Nutrition, May 1, 2000; 71(5): 1194 - 1200. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
