AJCN Cancer Health Disparities Conference
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Acuff, R. V.
Right arrow Articles by Lane, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Acuff, R. V.
Right arrow Articles by Lane, J. R.
Agricola
Right arrow Articles by Acuff, R. V.
Right arrow Articles by Lane, J. R.

American Journal of Clinical Nutrition, Vol 67, 459-464, Copyright © 1998 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Transport of deuterium-labeled tocopherols during pregnancy

RV Acuff, RG Dunworth, LW Webb and JR Lane
Eastman Center for Nutrition Research, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614-0410, USA. acuffr@access.etsu.edu

With use of deuterium-labeled isotopes of RRR- and all-rac-alpha- tocopheryl acetate, the transport of vitamin E in pregnancy was evaluated to determine whether the placenta discriminates between these compounds. Fifteen pregnant subjects were recruited 5 d before delivery to receive 15, 30, 75, 150, or 300 mg vitamin E/d in capsules containing d3-RRR-alpha-tocopheryl acetate and d6-all-rac-alpha- tocopheryl acetate (1:1, by wt). Maternal blood was obtained before dosing, at hospital admission, and at parturition. Cord blood samples were obtained at parturition. Deuterium-labeled and unlabeled tocopherol contents were determined by gas chromatography-mass spectrometry in plasma and lipoproteins (chylomicrons, VLDL, LDL, and HDL). Maternal plasma and lipoproteins obtained at delivery had higher concentrations of d3-RRR-alpha-tocopherol than d6-all-rac-alpha- tocopherol regardless of the vitamin E dose administered (P < 0.05). Cord plasma at delivery also had higher concentrations of d3-RRR-alpha- tocopherol than d6-all-rac-alpha-tocopherol in plasma irrespective of the dose administered (P < 0.05). In lipoproteins isolated from cord blood, tocopherol concentrations were greatest in the HDL fraction (P < 0.05), whereas in maternal blood they were greatest in the LDL fraction (P < 0.05). We conclude that the placental-fetal unit, the fetal liver, or both further discriminate between RRR- and all-rac-alpha-tocopherol.


This article has been cited by other articles:


Home page
 J. Nutr.Home page
A. R. Proteggente, R. Turner, J. Majewicz, G. Rimbach, A. M. Minihane, K. Kramer, and J. K. Lodge
Noncompetitive Plasma Biokinetics of Deuterium-Labeled Natural and Synthetic {alpha}-Tocopherol in Healthy Men with an apoE4 Genotype
J. Nutr., May 1, 2005; 135(5): 1063 - 1069.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. M. Madsen, M. L. S. Lindegaard, C. B. Andersen, P. Damm, and L. B. Nielsen
Human Placenta Secretes Apolipoprotein B-100-containing Lipoproteins
J. Biol. Chem., December 31, 2004; 279(53): 55271 - 55276.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. Landvik
Vitamin E from supplements has good bioavailability
Am. J. Clinical Nutrition, September 1, 2004; 80(3): 784 - 785.
[Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
W. L Stone, I. LeClair, T. Ponder, G. Baggs, and B. B. Reis
Infants discriminate between natural and synthetic vitamin E
Am. J. Clinical Nutrition, April 1, 2003; 77(4): 899 - 906.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
R. Brigelius-Flohe, F. J Kelly, J. T Salonen, J. Neuzil, J.-M. Zingg, and A. Azzi
The European perspective on vitamin E: current knowledge and future research
Am. J. Clinical Nutrition, October 1, 2002; 76(4): 703 - 716.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
C. Lauridsen, H. Engel, S. K. Jensen, A. M. Craig, and M. G. Traber
Lactating Sows and Suckling Piglets Preferentially Incorporate RRR- over All-rac-{alpha}-Tocopherol into Milk, Plasma and Tissues
J. Nutr., June 1, 2002; 132(6): 1258 - 1264.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. W Leonard, Y. Terasawa, R. V Farese Jr, and M. G Traber
Incorporation of deuterated RRR- or all-rac-{alpha}-tocopherol in plasma and tissues of {alpha}-tocopherol transfer protein-null mice
Am. J. Clinical Nutrition, March 1, 2002; 75(3): 555 - 560.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
R. BRIGELIUS-FLOHÉ and M. G. TRABER
Vitamin E: function and metabolism
FASEB J, July 1, 1999; 13(10): 1145 - 1155.
[Abstract] [Full Text]

Home page
 Am. J. Clin. Nutr.Home page
G. W Burton, K. U Ingold, M. G Traber, and H. J Kayden
Reply to W Cohn
Am. J. Clinical Nutrition, January 1, 1999; 69(1): 157 - 158.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-i. Jishage, M. Arita, K. Igarashi, T. Iwata, M. Watanabe, M. Ogawa, O. Ueda, N. Kamada, K. Inoue, H. Arai, et al.
alpha -Tocopherol Transfer Protein Is Important for the Normal Development of Placental Labyrinthine Trophoblasts in Mice
J. Biol. Chem., January 12, 2001; 276(3): 1669 - 1672.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by The American Society for Nutrition