| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 67, 858-866, Copyright © 1998 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
JV Woodside, JW Yarnell, D McMaster, IS Young, DL Harmon, EE McCrum, CC Patterson, KF Gey, AS Whitehead and A Evans
School of Clinical Medicine, The Queen's University of Belfast, United Kingdom. p9495754@qub.ac.uk
Mild hyperhomocysteinemia is accepted as a risk factor for premature cardiovascular disease. In a population with a high prevalence of cardiovascular disease, we screened a group of clinically healthy working men aged 30-49 y (n = 509) for plasma homocysteine and 5,10- methylene tetrahydrofolate reductase (MTHFR) genotype status. Those with mildly elevated homocysteine concentrations (> or = 8.34 micromol/L) were selected for intervention. In a randomized, factorial- design, controlled trial we assessed the effects of B-group vitamins and antioxidant vitamin supplementation on homocysteine concentrations. The 132 men were randomly assigned to one of four groups: supplementation with B-group vitamins alone (1 mg folic acid, 7.2 mg pyridoxine, and 0.02 mg cyanocobalamin), antioxidant vitamins alone (150 mg ascorbic acid, 67 mg RRR-alpha-tocopherol, and 9 mg beta- carotene), B-group vitamins with antioxidant vitamins, or placebo. Intervention was double-blind. A total of 101 men completed the 8-wk intervention. When homocysteine concentrations were analyzed by group, significant (P < 0.001) decreases (32.0% and 30.0%, respectively) were observed in both groups receiving B-group vitamins either with or without antioxidants. The effect of B-group vitamins alone over 8 wk was a reduction in homocysteine concentrations of 27.9% (95% CI: 22.0%, 33.3%; P < 0.001) whereas antioxidants alone produced a nonsignificant increase of 5.1% (95% CI: -2.8%, 13.6%; P = 0.21). There was no evidence of any interaction between the two groups of vitamins. The effect of B-group vitamin supplementation seemed to depend on MTHFR genotype. Supplementation with the B-group vitamins with or without antioxidants reduced homocysteine in the men with mildly elevated concentrations, and hence may be effective in reducing cardiovascular risk.
This article has been cited by other articles:
|
|
 |
|
  R. M Winkels, I. A Brouwer, R. Clarke, M. B Katan, and P. Verhoef Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial Am. J. Clinical Nutrition, August 1, 2008; 88(2): 348 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Homocysteine Lowering Trialists' Collaboration Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials Am. J. Clinical Nutrition, October 1, 2005; 82(4): 806 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. Kilicdag, T. Bagis, E. Tarim, E. Aslan, S. Erkanli, E. Simsek, B. Haydardedeoglu, and E. Kuscu Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial Hum. Reprod., June 1, 2005; 20(6): 1521 - 1528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Iso, Y. Moriyama, S. Sato, A. Kitamura, T. Tanigawa, K. Yamagishi, H. Imano, T. Ohira, T. Okamura, Y. Naito, et al. Serum Total Homocysteine Concentrations and Risk of Stroke and Its Subtypes in Japanese Circulation, June 8, 2004; 109(22): 2766 - 2772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. McKay, J. M. Berkowitz, J. B. Blumberg, and J. P. Goldberg Communicating Cardiovascular Disease Risk Due to Elevated Homocysteine Levels: Using the EPPM to Develop Print Materials Health Educ Behav, June 1, 2004; 31(3): 355 - 371. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Little, L. Sharp, S. Duthie, and S. Narayanan Colon Cancer and Genetic Variation in Folate Metabolism: The Clinical Bottom Line J. Nutr., November 1, 2003; 133(11): 3758S - 3766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F Remacha, J. Cadafalch, P. Sarda, M. Barcelo, and M. Fuster Vitamin B-12 metabolism in HIV-infected patients in the age of highly active antiretroviral therapy: role of homocysteine in assessing vitamin B-12 status Am. J. Clinical Nutrition, February 1, 2003; 77(2): 420 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A Heuberger, A. I Fisher, P. F Jacques, R. Klein, B. E. Klein, M. Palta, and J. A Mares-Perlman Relation of blood homocysteine and its nutritional determinants to age-related maculopathy in the third National Health and Nutrition Examination Survey Am. J. Clinical Nutrition, October 1, 2002; 76(4): 897 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Tice, E. Ross, P. G. Coxson, I. Rosenberg, M. C. Weinstein, M. G. M. Hunink, P. A. Goldman, L. Williams, and L. Goldman Cost-effectiveness of Vitamin Therapy to Lower Plasma Homocysteine Levels for the Prevention of Coronary Heart Disease: Effect of Grain Fortification and Beyond JAMA, August 22, 2001; 286(8): 936 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Descombes, O. Boulat, L.-F. Bersier, and G. Fellay Difference in the homocysteine-lowering effect of folic acid in haemodialysis patients with and without occlusive vascular disease Nephrol. Dial. Transplant., March 1, 2001; 16(3): 585 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jang, J. H. Lee, E. Y. Cho, N. S. Chung, D. Topham, and B. Balderston Differences in body fat distribution and antioxidant status in Korean men with cardiovascular disease with or without diabetes Am. J. Clinical Nutrition, January 1, 2001; 73(1): 68 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Polidori, A. Cherubini, U. Senin, and P. Mecocci Hyperhomocysteinemia and Oxidative Stress in Ischemic Stroke Stroke, January 1, 2001; 32(1): 275 - 278. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Halliwell Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward? Cardiovasc Res, August 18, 2000; 47(3): 410 - 418. [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Booth, E. E.L. Wang, and with the Canadian Task Force on Preventive Health Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events Can. Med. Assoc. J., July 1, 2000; 163(1): 21 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Kirkham, M. Prengler, D. K.M. Hewes, and V. Ganesan Risk Factors for Arterial Ischemic Stroke in Children J Child Neurol, May 1, 2000; 15(5): 299 - 307. [Abstract] [PDF]
|
|
|
|
 |
|
 M.A. Eastwood Interaction of dietary antioxidants in vivo: how fruit and vegetables prevent disease? QJM, September 1, 1999; 92(9): 527 - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F J Kirkham Stroke in childhood Arch. Dis. Child., July 1, 1999; 81(1): 85 - 89. [Full Text]
|
|
|
|
|
|
P B. Duell, M R. Malinow, J. V Woodside, I. S Young, J. W. Yarnell, D. McMaster, C. C Patterson, E. E McCrum, A. Evans, K F. Gey, et al. Effects of folic acid on homocysteine in persons classified by methylenetetrahydrofolate reductase genotype Am. J. Clinical Nutrition, June 1, 1999; 69(6): 1287 - 1289. [Full Text] [PDF]
|
|
|
|
 |
|
 E. BOURDON, N. LOREAU, and D. BLACHE Glucose and free radicals impair the antioxidant properties of serum albumin FASEB J, February 1, 1999; 13(2): 233 - 244. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
