| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 67, 972S-977S, Copyright © 1998 by The American Society for Clinical Nutrition, Inc
REVIEW ARTICLES |
ZL Harris, LW Klomp and JD Gitlin
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, USA.
Aceruloplasminemia is an autosomal recessive disorder characterized by progressive neurodegeneration of the retina and basal ganglia associated with specific inherited mutations in the ceruloplasmin gene. Clinical and pathologic studies in patients with aceruloplasminemia revealed a marked accumulation of iron in affected parenchymal tissues, a finding consistent with early work identifying ceruloplasmin as a ferroxidase and with recent findings showing an essential role for a homologous copper oxidase in iron metabolism in yeast. The presence of neurologic symptoms in aceruloplasminemia is unique among the known inherited and acquired disorders of iron metabolism; recent studies revealed an essential role for astrocyte-specific expression of ceruloplasmin in iron metabolism and neuronal survival in the central nervous system. Recognition of aceruloplasminemia provides new insights into the genetic and environmental determinants of copper metabolism and has important implications for our understanding of the role of copper in human neurodegenerative diseases.
This article has been cited by other articles:
|
|
 |
|
  E. Sedlak, G. Zoldak, and P. Wittung-Stafshede Role of Copper in Thermal Stability of Human Ceruloplasmin Biophys. J., February 15, 2008; 94(4): 1384 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Stoj, A. J. Augustine, E. I. Solomon, and D. J. Kosman Structure-Function Analysis of the Cuprous Oxidase Activity in Fet3p from Saccharomyces cerevisiae J. Biol. Chem., March 16, 2007; 282(11): 7862 - 7868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Stasi, D. Nagel, X. Yang, L. Ren, T. Mittag, and J. Danias Ceruloplasmin Upregulation in Retina of Murine and Human Glaucomatous Eyes Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 727 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Dunaief Iron Induced Oxidative Damage As a Potential Factor in Age-Related Macular Degeneration: The Cogan Lecture Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 4660 - 4664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chen, G. Huang, T. Su, H. Gao, Z. K. Attieh, A. T. McKie, G. J. Anderson, and C. D. Vulpe Decreased Hephaestin Activity in the Intestine of Copper-Deficient Mice Causes Systemic Iron Deficiency J. Nutr., May 1, 2006; 136(5): 1236 - 1241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Wiggins, M. Goyal, B. L. Wharram, and R. C. Wiggins Antioxidant Ceruloplasmin Is Expressed by Glomerular Parietal Epithelial Cells and Secreted into Urine in Association with Glomerular Aging and High-Calorie Diet J. Am. Soc. Nephrol., May 1, 2006; 17(5): 1382 - 1387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Ravia, R. M. Stephen, F. K. Ghishan, and J. F. Collins Menkes Copper ATPase (Atp7a) Is a Novel Metal-responsive Gene in Rat Duodenum, and Immunoreactive Protein Is Present on Brush-border and Basolateral Membrane Domains J. Biol. Chem., October 28, 2005; 280(43): 36221 - 36227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Fox Mix 'n' match metalloproteins Blood, June 15, 2004; 103(12): 4378 - 4379. [Full Text] [PDF]
|
|
|
|
|
|
A.-S. Zhang, S. Xiong, H. Tsukamoto, and C. A. Enns Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes Blood, February 15, 2004; 103(4): 1509 - 1514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shim and Z. L. Harris Genetic Defects in Copper Metabolism J. Nutr., May 1, 2003; 133(5): 1527S - 1531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Donovan, A. Brownlie, M. O. Dorschner, Y. Zhou, S. J. Pratt, B. H. Paw, R. B. Phillips, C. Thisse, B. Thisse, and L. I. Zon The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1) Blood, December 15, 2002; 100(13): 4655 - 4659. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Fleming, J. R. Ahmann, M. C. Migas, A. Waheed, H. P. Koeffler, H. Kawabata, R. S. Britton, B. R. Bacon, and W. S. Sly Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis PNAS, August 6, 2002; 99(16): 10653 - 10658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Takeuchi, M Yoshikawa, T Tsujino, S Kohno, N Tsukamoto, A Shiroi, E Kikuchi, H Fukui, and H Miyajima A case of aceruloplasminaemia: abnormal serum ceruloplasmin protein without ferroxidase activity J. Neurol. Neurosurg. Psychiatry, April 1, 2002; 72(4): 543 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. N. Roy and N. C. Andrews Recent advances in disorders of iron metabolism: mutations, mechanisms and modifiers Hum. Mol. Genet., October 1, 2001; 10(20): 2181 - 2186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Andrews Mining copper transport genes PNAS, June 5, 2001; 98(12): 6543 - 6545. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Grosell, J. C. McGeer, and C. M. Wood Plasma copper clearance and biliary copper excretion are stimulated in copper-acclimated trout Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2001; 280(3): R796 - R806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Mazumder and P. L. Fox Delayed Translational Silencing of Ceruloplasmin Transcript in Gamma Interferon-Activated U937 Monocytic Cells: Role of the 3' Untranslated Region Mol. Cell. Biol., October 1, 1999; 19(10): 6898 - 6905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. L. Harris, A. P. Durley, T. K. Man, and J. D. Gitlin Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux PNAS, September 14, 1999; 96(19): 10812 - 10817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. O. Peña, J. Lee, and D. J. Thiele A Delicate Balance: Homeostatic Control of Copper Uptake and Distribution J. Nutr., July 1, 1999; 129(7): 1251 - 1260. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Danzeisen, C. Fosset, Z. Chariana, K. Page, S. David, and H. J. McArdle Placental ceruloplasmin homolog is regulated by iron and copper and is implicated in iron metabolism Am J Physiol Cell Physiol, March 1, 2002; 282(3): C472 - C478. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
