| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 68, 794-801, Copyright © 1998 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
NL Keim, JS Stern and PJ Havel
US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, San Francisco, CA 94129, USA. nkeim@whnrc.usda.gov
BACKGROUND: On the basis of observations in rodents, leptin is thought to play a key role in the regulation of energy expenditure and food intake, but less is known of its influence on ingestive behavior and energy balance in humans. OBJECTIVE: We examined the effect in women of a chronic energy deficit on plasma leptin concentrations and self- reported appetite and explored possible relations between leptin and appetite sensations. DESIGN: Twelve healthy women (body mass index, in kg/m2: 23-37) participated in a metabolic ward study in which 3 wk of neutral energy balance was followed by 12 wk of energy deficit (energy intake reduced by 2 MJ/d and energy expenditure increased by 0.8 MJ/d). Body weight and composition were monitored, fasting leptin concentrations were measured 4 times, and feelings of hunger, fullness, desire to eat, and prospective consumption were monitored hourly throughout the day on 7 selected days. RESULTS: Adiposity-adjusted leptin decreased by 54% after 1 wk of a moderate energy deficit and remained low after 6 and 12 wk. Leptin was associated with self- reported hunger, desire to eat, and prospective consumption (range of r: -0.6 to -0.7, P < 0.01). The greatest hunger increase coincided with the largest percentage drop in circulating leptin and the lowest final leptin concentration. The relation between leptin and hunger was not influenced by amount of weight or body fat loss. CONCLUSIONS: These findings support the idea that leptin is a physiologic regulator of hunger during energy deficits in humans; the role of leptin in the long- term regulation of food intake warrants further study.
This article has been cited by other articles:
|
|
 |
|
  S. Chearskul, E. Delbridge, A. Shulkes, J. Proietto, and A. Kriketos Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1238 - 1246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E Arsenault, P. J Havel, D. L. de Romana, M. E Penny, M. D Van Loan, and K. H Brown Longitudinal measures of circulating leptin and ghrelin concentrations are associated with the growth of young Peruvian children but are not affected by zinc supplementation Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1111 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Hayes, C. K. Miller, J. S. Ulbrecht, J. L. Mauger, L. Parker-Klees, M. D. Gutschall, D. C. Mitchell, H. Smiciklas-Wright, and M. Covasa A Carbohydrate-Restricted Diet Alters Gut Peptides and Adiposity Signals in Men and Women with Metabolic Syndrome J. Nutr., August 1, 2007; 137(8): 1944 - 1950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Smith, J. E. Blundell, C. Burns, C. Ellero, B. E. Schroeder, N. C. Kesty, K. S. Chen, A. E. Halseth, C. W. Lush, and C. Weyer Pramlintide treatment reduces 24-h caloric intake and meal sizes and improves control of eating in obese subjects: a 6-wk translational research study Am J Physiol Endocrinol Metab, August 1, 2007; 293(2): E620 - E627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Gosman, H. I. Katcher, and R. S. Legro Obesity and the role of gut and adipose hormones in female reproduction Hum. Reprod. Update, September 1, 2006; 12(5): 585 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Nogueiras, S. Tovar, S. E Mitchell, P. Barrett, D V. Rayner, C. Dieguez, and L. M Williams Negative energy balance and leptin regulate neuromedin-U expression in the rat pars tuberalis. J. Endocrinol., August 1, 2006; 190(2): 545 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W Krieger, H. S Sitren, M. J Daniels, and B. Langkamp-Henken Effects of variation in protein and carbohydrate intake on body mass and composition during energy restriction: a meta-regression 1 Am. J. Clinical Nutrition, February 1, 2006; 83(2): 260 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Lofgren, I. Andersson, B. Adolfsson, B.-M. Leijonhufvud, K. Hertel, J. Hoffstedt, and P. Arner Long-Term Prospective and Controlled Studies Demonstrate Adipose Tissue Hypercellularity and Relative Leptin Deficiency in the Postobese State J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6207 - 6213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Moran, N. D. Luscombe-Marsh, M. Noakes, G. A. Wittert, J. B. Keogh, and P. M. Clifton The Satiating Effect of Dietary Protein Is Unrelated to Postprandial Ghrelin Secretion J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5205 - 5211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mars, C. de Graaf, L. C. de Groot, and F. J Kok Decreases in fasting leptin and insulin concentrations after acute energy restriction and subsequent compensation in food intake Am. J. Clinical Nutrition, March 1, 2005; 81(3): 570 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Blom, A. Stafleu, C. de Graaf, F. J Kok, G. Schaafsma, and H. F. Hendriks Ghrelin response to carbohydrate-enriched breakfast is related to insulin Am. J. Clinical Nutrition, February 1, 2005; 81(2): 367 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Spiegel, R. Leproult, M. L'Hermite-Baleriaux, G. Copinschi, P. D. Penev, and E. Van Cauter Leptin Levels Are Dependent on Sleep Duration: Relationships with Sympathovagal Balance, Carbohydrate Regulation, Cortisol, and Thyrotropin J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5762 - 5771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. McDuffie, P. A. Riggs, K. A. Calis, R. J. Freedman, E. A. Oral, A. M. DePaoli, and J. A. Yanovski Effects of Exogenous Leptin on Satiety and Satiation in Patients with Lipodystrophy and Leptin Insufficiency J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4258 - 4263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Moran, M. Noakes, P. M. Clifton, G. A. Wittert, L. Tomlinson, C. Galletly, N. D. Luscombe, and R. J. Norman Ghrelin and Measures of Satiety Are Altered in Polycystic Ovary Syndrome But Not Differentially Affected by Diet Composition J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3337 - 3344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Hanusch-Enserer, E. Cauza, G. Brabant, A. Dunky, H. Rosen, G. Pacini, H. Tuchler, R. Prager, and M. Roden Plasma Ghrelin in Obesity before and after Weight Loss after Laparoscopical Adjustable Gastric Banding J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3352 - 3358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. de Graaf, W. A. Blom, P. A. Smeets, A. Stafleu, and H. F. Hendriks Biomarkers of satiation and satiety Am. J. Clinical Nutrition, June 1, 2004; 79(6): 946 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. T. Bloomgarden The 1st World Congress on the Insulin Resistance Syndrome Diabetes Care, February 1, 2004; 27(2): 602 - 609. [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Havel Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism Diabetes, February 1, 2004; 53(90001): S143 - 151. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. C. Benoit, D. J. Clegg, R. J. Seeley, and S. C. Woods Insulin and Leptin as Adiposity Signals Recent Prog. Horm. Res., January 1, 2004; 59(1): 267 - 285. [Abstract] [Full Text]
|
|
|
|
|
|
D. S. Weigle, D. E. Cummings, P. D. Newby, P. A. Breen, R. S. Frayo, C. C. Matthys, H. S. Callahan, and J. Q. Purnell Roles of Leptin and Ghrelin in the Loss of Body Weight Caused by a Low Fat, High Carbohydrate Diet J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1577 - 1586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Faraj, P. J. Havel, S. Phelis, D. Blank, A. D. Sniderman, and K. Cianflone Plasma Acylation-Stimulating Protein, Adiponectin, Leptin, and Ghrelin before and after Weight Loss Induced by Gastric Bypass Surgery in Morbidly Obese Subjects J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1594 - 1602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Schultes, K. M. Oltmanns, W. Kern, H. L. Fehm, J. Born, and A. Peters Modulation of Hunger by Plasma Glucose and Metformin J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1133 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S Elliott, N. L Keim, J. S Stern, K. Teff, and P. J Havel Fructose, weight gain, and the insulin resistance syndrome Am. J. Clinical Nutrition, November 1, 2002; 76(5): 911 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Havel Peripheral Signals Conveying Metabolic Information to the Brain: Short-Term and Long-Term Regulation of Food Intake and Energy Homeostasis Experimental Biology and Medicine, December 1, 2001; 226(11): 963 - 977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Herrmann, M. L. Bean, T. M. Black, P. Wang, and R. A. Coleman High Glycemic Index Carbohydrate Diet Alters the Diurnal Rhythm of Leptin But Not Insulin Concentrations Experimental Biology and Medicine, December 1, 2001; 226(11): 1037 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lonnerdal and P. J Havel Serum leptin concentrations in infants: effects of diet, sex, and adiposity Am. J. Clinical Nutrition, August 1, 2000; 72(2): 484 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Polito, A. Fabbri, A. Ferro-Luzzi, M. Cuzzolaro, L. Censi, D. Ciarapica, E. Fabbrini, and D. Giannini Basal metabolic rate in anorexia nervosa: relation to body composition and leptin concentrations Am. J. Clinical Nutrition, June 1, 2000; 71(6): 1495 - 1502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Doucet, S. St. Pierre, N. Alméras, P. Mauriège, D. Richard, and A. Tremblay Changes in Energy Expenditure and Substrate Oxidation Resulting from Weight Loss in Obese Men and Women: Is There an Important Contribution of Leptin? J. Clin. Endocrinol. Metab., April 1, 2000; 85(4): 1550 - 1556. [Abstract] [Full Text]
|
|
|
|
 |
|
 I. Murray, P. J. Havel, A. D. Sniderman, and K. Cianflone Reduced Body Weight, Adipose Tissue, and Leptin Levels Despite Increased Energy Intake in Female Mice Lacking Acylation-Stimulating Protein Endocrinology, March 1, 2000; 141(3): 1041 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A Ainslie, J. Proietto, B. C Fam, and A. W Thorburn Short-term, high-fat diets lower circulating leptin concentrations in rats1 Am. J. Clinical Nutrition, February 1, 2000; 71(2): 438 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Romon, P. Lebel, C. Velly, N. Marecaux, J. C. Fruchart, and J. Dallongeville Leptin response to carbohydrate or fat meal and association with subsequent satiety and energy intake Am J Physiol Endocrinol Metab, November 1, 1999; 277(5): E855 - E861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Hagan, P. J. Havel, R. J. Seeley, S. C. Woods, N. N. Ekhator, D. G. Baker, K. K. Hill, M. D. Wortman, A. H. Miller, R. L. Gingerich, et al. Cerebrospinal Fluid and Plasma Leptin Measurements: Covariability with Dopamine and Cortisol in Fasting Humans J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3579 - 3585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J Havel Mechanisms regulating leptin production: implications for control of energy balance Am. J. Clinical Nutrition, September 1, 1999; 70(3): 305 - 306. [Full Text] [PDF]
|
|
|
|
|
|
B. E Wisse, L A. Campfield, E. B Marliss, J. A Morais, R. Tenenbaum, and R. Gougeon Effect of prolonged moderate and severe energy restriction and refeeding on plasma leptin concentrations in obese women Am. J. Clinical Nutrition, September 1, 1999; 70(3): 321 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Weinsier Genes and Obesity: Is There Reason To Change Our Behaviors? Ann Intern Med, June 1, 1999; 130(11): 938 - 939. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
