AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sanderson, I. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sanderson, I. R.
Agricola
Right arrow Articles by Sanderson, I. R.

American Journal of Clinical Nutrition, Vol 68, 999-1005, Copyright © 1998 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Dietary regulation of genes expressed in the developing intestinal epithelium

IR Sanderson
Developmental Gastroenterology Laboratory, Harvard Clinical Nutrition Research Center, Harvard Medical School, Boston, MA, USA. i.r.sanderson@mds.qmw.ac.uk

Gene expression is central to the pathogenesis of many disorders. An ability to alter the expression of genes would, if their relation to disease processes were fully understood, constitute a new modality of treatment. This lecture examines the evidence that nutritional factors can regulate genes in the gastrointestinal epithelium and it discusses the physiologic relevance of such alterations in gene expression. Dietary regulation of the genes expressed by the epithelium confers 3 fundamental advantages for mammals. It enables the epithelium to adapt to the luminal environment to better digest and absorb food; it provides the means whereby breast milk can influence the development of the gastrointestinal tract; and, when the proteins expressed by the epithelium act on the immune system, it constitutes a signaling mechanism from the intestinal lumen to the body's defenses. Each of these mechanisms is amenable to manipulation for therapeutic purposes.


This article has been cited by other articles:


Home page
 GutHome page
Y Ohtsuka, J Lee, D S Stamm, and I R Sanderson
MIP-2 secreted by epithelial cells increases neutrophil and lymphocyte recruitment in the mouse intestine
Gut, October 1, 2001; 49(4): 526 - 533.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by The American Society for Nutrition