AJCN Cancer Health Disparities Conference
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maas, M. I.
Right arrow Articles by Jansen, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maas, M. I.
Right arrow Articles by Jansen, J. B.
Agricola
Right arrow Articles by Maas, M. I.
Right arrow Articles by Jansen, J. B.

American Journal of Clinical Nutrition, Vol 68, 1272-1275, Copyright © 1998 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

The nondigestible fat sucrose polyester does not stimulate gallbladder emptying in humans

MI Maas, WP Hopman, MB Katan and JB Jansen
Department of Gastroenterology and Hepatology, University Hospital Nijmegen, The Netherlands.

BACKGROUND: We determined the effect of oral ingestion of sucrose polyester, which was approved as a fat replacer in the United States, on gallbladder motility and on the release of cholecystokinin, the hormone that mediates gallbladder emptying. OBJECTIVE: Our objective was to measure effects of sucrose polyester on gallbladder emptying and cholecystokinin release. DESIGN: Eight healthy volunteers (3 men and 5 women) drank 60 mL sucrose polyester, digestible fat, or saline solution in a balanced crossover design on 3 separate days. RESULTS: Mean (+/-SEM) gallbladder emptying, when integrated over time, was low in response to both sucrose polyester (-150 +/- 214 mL x 120 min) and saline solution (-89 +/- 123 mL x 120 min). In contrast, there was marked emptying in response to digestible fat (1069 +/- 253 mL x 120 min). Sucrose polyester did not affect plasma cholecystokinin concentrations (-9.3 +/- 15.0 pmol x 120 min/L), whereas digestible fat resulted in a significant increase (89.5 +/- 44.8 pmol x 120 min/L, P = 0.014) compared with saline solution (-3.0 +/- 13.8 pmol x 120 min/L). CONCLUSIONS: Ingestion of sucrose polyester, in contrast with digestible fat, did not stimulate gallbladder emptying or release of cholecystokinin.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. J. Jandacek, N. Anderson, M. Liu, S. Zheng, Q. Yang, and P. Tso
Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene
Am J Physiol Gastrointest Liver Physiol, February 1, 2005; 288(2): G292 - G299.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Public HealthHome page
J. Levine, J. D. Gussow, D. Hastings, and A. Eccher
Authors' Financial Relationships With the Food and Beverage Industry and Their Published Positions on the Fat Substitute Olestra
Am J Public Health, April 1, 2003; 93(4): 664 - 669.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by The American Society for Nutrition