| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communications |
To determine whether the satiating effects of nutrients in the small intestine are lower in obese than in nonobese people, 9 healthy, obese men [age: 18–33 y; body mass index (BMI; in kg/m2) 30.4–40.8] and 11 healthy, nonobese men (age: 18–33 y; BMI: 19.1–26.4) received an intraduodenal infusion of saline (control), lipid (11.97 kJ/min, or 2.86 kcal/min), or glucose (11.97 kJ/min) for 120 min on separate days. Fullness, hunger, and nausea were assessed by visual analogue scales. After the infusions, a meal was offered and food intake was quantified. There was no difference in appetite ratings between the obese and nonobese subjects during the infusions, in the amount or macronutrient composition of food eaten after the infusions, or in the time taken to eat the meals. Both the lipid and glucose infusions were associated with greater fullness than the control infusion. The energy content of the food eaten was less after the lipid infusion than after either the control or glucose infusion (P < 0.01); lipid infusion suppressed energy intake by 22% compared with the control infusion and by 15% compared with the glucose infusion. Suppression of energy intake after intraduodenal nutrient infusions was due to slower eating (P < 0.01). Intraduodenal infusions of fat suppressed appetite and food intake more than did equienergetic infusions of carbohydrate in both obese and nonobese young men, and the responses to intraduodenal fat and glucose were not affected by obesity. The latter observation suggests that established obesity is not associated with reduced small-intestinal responses to dietary fat or carbohydrate. Am J Clin Nutr 1999;69:6–12.
Key Words: Appetite • hunger • fat • carbohydrate • small intestine • duodenum • satiety • obesity • men
This article has been cited by other articles:
|
|
 |
|
  K. L Feltrin, T. J Little, J. H Meyer, M. Horowitz, T. Rades, J. Wishart, and C. Feinle-Bisset Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1181 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. Pilichiewicz, P. Papadopoulos, I. M. Brennan, T. J. Little, J. H. Meyer, J. M. Wishart, M. Horowitz, and C. Feinle-Bisset Load-dependent effects of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2170 - R2178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J Little, M. Horowitz, and C. Feinle-Bisset Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity Am. J. Clinical Nutrition, September 1, 2007; 86(3): 531 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. Pilichiewicz, R. Chaikomin, I. M. Brennan, J. M. Wishart, C. K. Rayner, K. L. Jones, A. J. P. M. Smout, M. Horowitz, and C. Feinle-Bisset Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E743 - E753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Pilichiewicz, T. J. Little, I. M. Brennan, J. H. Meyer, J. M. Wishart, B. Otto, M. Horowitz, and C. Feinle-Bisset Effects of load, and duration, of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R668 - R677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Little, K. L. Feltrin, M. Horowitz, A. J. P. M. Smout, T. Rades, J. H. Meyer, A. N. Pilichiewicz, J. Wishart, and C. Feinle-Bisset Dose-related effects of lauric acid on antropyloroduodenal motility, gastrointestinal hormone release, appetite, and energy intake in healthy men Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R1090 - R1098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. D Luscombe-Marsh, M. Noakes, G. A Wittert, J. B Keogh, P. Foster, and P. M Clifton Carbohydrate-restricted diets high in either monounsaturated fat or protein are equally effective at promoting fat loss and improving blood lipids Am. J. Clinical Nutrition, April 1, 2005; 81(4): 762 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Moran, M. Noakes, P. M. Clifton, G. A. Wittert, L. Tomlinson, C. Galletly, N. D. Luscombe, and R. J. Norman Ghrelin and Measures of Satiety Are Altered in Polycystic Ovary Syndrome But Not Differentially Affected by Diet Composition J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3337 - 3344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Feinle, D. O'Donovan, S. Doran, J. M. Andrews, J. Wishart, I. Chapman, and M. Horowitz Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans Am J Physiol Gastrointest Liver Physiol, May 1, 2003; 284(5): G798 - G807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Boyd, D. G. O'Donovan, S. Doran, J. Wishart, I. M. Chapman, M. Horowitz, and C. Feinle High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men Am J Physiol Gastrointest Liver Physiol, February 1, 2003; 284(2): G188 - G196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Rayner, H. S. Park, S. M. Doran, I. M. Chapman, and M. Horowitz Effects of cholecystokinin on appetite and pyloric motility during physiological hyperglycemia Am J Physiol Gastrointest Liver Physiol, January 1, 2000; 278(1): G98 - G104. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
