| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communications |
Background: Epidemiologic studies have shown dietary antioxidants to be inversely correlated with ischemic heart disease.
Objective: We investigated whether dietary ß-carotene, vitamin C, and vitamin E were related to the risk of myocardial infarction (MI) in an elderly population.
Design: The study sample consisted of 4802 participants of the Rotterdam Study aged 55–95 y who were free of MI at baseline and for whom dietary data assessed by a semiquantitative food frequency questionnaire were available. During a 4-y follow-up period, 124 subjects had an MI. The association between energy-adjusted ß-carotene, vitamin C, and vitamin E intakes and risk of MI was examined by multivariate logistic regression.
Results: Risk of MI for the highest compared with the lowest tertile of ß-carotene intake was 0.55 (95% CI: 0.34, 0.83; P for trend = 0.013), adjusted for age, sex, body mass index, pack-years, income, education, alcohol intake, energy-adjusted intakes of vitamin C and E, and use of antioxidative vitamin supplements. When ß-carotene intakes from supplements were considered, the inverse relation with risk of MI was slightly more pronounced. Stratification by smoking status indicated that the association was most evident in current and former smokers. No association with risk of MI was observed for dietary vitamin C and vitamin E.
Conclusion: The results of this observational study in the elderly population of the Rotterdam Study support the hypothesis that high dietary ß-carotene intakes may protect against cardiovascular disease. We did not observe an association between vitamin C or vitamin E and MI.
Key Words: Myocardial infarction • ischemic heart disease • dietary antioxidants • ß-carotene • vitamin C • vitamin E • vitamin supplements • elderly • the Rotterdam Study • Netherlands
This article has been cited by other articles:
|
|
 |
|
  B. Buijsse, E. J. M. Feskens, L. Kwape, F. J. Kok, and D. Kromhout Both {alpha}- and -Carotene, but Not Tocopherols and Vitamin C, Are Inversely Related to 15-Year Cardiovascular Mortality in Dutch Elderly Men J. Nutr., February 1, 2008; 138(2): 344 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-N. Vercambre, A. Fournier, M.-C. Boutron-Ruault, F. Clavel-Chapelon, V. Ringa, and C. Berr Differential Dietary Nutrient Intake according to Hormone Replacement Therapy Use: An Underestimated Confounding Factor in Epidemiologic Studies? Am. J. Epidemiol., December 15, 2007; 166(12): 1451 - 1460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Siekmeier, C. Steffen, and W. Marz Role of Oxidants and Antioxidants in Atherosclerosis: Results of In Vitro and In Vivo Investigations Journal of Cardiovascular Pharmacology and Therapeutics, December 1, 2007; 12(4): 265 - 282. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Reitz, T. den Heijer, C. van Duijn, A. Hofman, and M.M.B. Breteler Relation between smoking and risk of dementia and Alzheimer disease: The Rotterdam Study Neurology, September 4, 2007; 69(10): 998 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Voutilainen, T. Nurmi, J. Mursu, and T. H Rissanen Carotenoids and cardiovascular health Am. J. Clinical Nutrition, June 1, 2006; 83(6): 1265 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Deicher, F. Ziai, C. Bieglmayer, M. Schillinger, and W. H. Horl Low Total Vitamin C Plasma Level Is a Risk Factor for Cardiovascular Morbidity and Mortality in Hemodialysis Patients J. Am. Soc. Nephrol., June 1, 2005; 16(6): 1811 - 1818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Tucker, J. Hallfrisch, N. Qiao, D. Muller, R. Andres, and J. L. Fleg The Combination of High Fruit and Vegetable and Low Saturated Fat Intakes Is More Protective against Mortality in Aging Men than Is Either Alone: The Baltimore Longitudinal Study of Aging J. Nutr., March 1, 2005; 135(3): 556 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Trumbo The Level of Evidence for Permitting a Qualified Health Claim: FDA's Review of the Evidence for Selenium and Cancer and Vitamin E and Heart Disease J. Nutr., February 1, 2005; 135(2): 354 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Genkinger, E. A. Platz, S. C. Hoffman, G. W. Comstock, and K. J. Helzlsouer Fruit, Vegetable, and Antioxidant Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality in a Community-dwelling Population in Washington County, Maryland Am. J. Epidemiol., December 15, 2004; 160(12): 1223 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Knekt, J. Ritz, M. A Pereira, E. J O'Reilly, K. Augustsson, G. E Fraser, U. Goldbourt, B. L Heitmann, G. Hallmans, S. Liu, et al. Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts Am. J. Clinical Nutrition, December 1, 2004; 80(6): 1508 - 1520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Tornwall, J. Virtamo, P. A. Korhonen, M. J. Virtanen, P. R. Taylor, D. Albanes, and J. K. Huttunen Effect of {alpha}-tocopherol and {beta}-carotene supplementation on coronary heart disease during the 6-year post-trial follow-up in the ATBC study Eur. Heart J., July 1, 2004; 25(13): 1171 - 1178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Simon, M. A. Murtaugh, M. D. Gross, C. M. Loria, S. B. Hulley, and D. R. Jacobs Jr. Relation of Ascorbic Acid to Coronary Artery Calcium: The Coronary Artery Risk Development in Young Adults Study Am. J. Epidemiol., March 15, 2004; 159(6): 581 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Dwyer, M. J. Paul-Labrador, J. Fan, A. M. Shircore, C. N. B. Merz, and K. M. Dwyer Progression of Carotid Intima-Media Thickness and Plasma Antioxidants: The Los Angeles Atherosclerosis Study Arterioscler. Thromb. Vasc. Biol., February 1, 2004; 24(2): 313 - 319. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. M. Nam, K. W. Oh, K. H. Lee, S. H. Jee, S. Y. Cho, W. H. Shim, and I. Suh Vitamin C Intake and Risk of Ischemic Heart Disease in a Population with a High Prevalence of Smoking J. Am. Coll. Nutr., October 1, 2003; 22(5): 372 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Holmquist, S. Larsson, A. Wolk, and U. de Faire Multivitamin Supplements Are Inversely Associated with Risk of Myocardial Infarction in Men and Women--Stockholm Heart Epidemiology Program (SHEEP) J. Nutr., August 1, 2003; 133(8): 2650 - 2654. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Osganian, M. J. Stampfer, E. Rimm, D. Spiegelman, F. B. Hu, J. E. Manson, and W. C. Willett Vitamin C and risk of coronary heart disease in women J. Am. Coll. Cardiol., July 16, 2003; 42(2): 246 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U.S. Preventive Services Task Force* Routine Vitamin Supplementation To Prevent Cancer and Cardiovascular Disease: Recommendations and Rationale Ann Intern Med, July 1, 2003; 139(1): 51 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Morris and S. Carson Routine Vitamin Supplementation To Prevent Cardiovascular Disease: A Summary of the Evidence for the U.S. Preventive Services Task Force Ann Intern Med, July 1, 2003; 139(1): 56 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K Osganian, M. J Stampfer, E. Rimm, D. Spiegelman, J. E Manson, and W. C Willett Dietary carotenoids and risk of coronary artery disease in women Am. J. Clinical Nutrition, June 1, 2003; 77(6): 1390 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Gotto Jr Antioxidants, statins, and atherosclerosis J. Am. Coll. Cardiol., April 2, 2003; 41(7): 1205 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Mooradian Cardiovascular Disease in Type 2 Diabetes Mellitus: Current Management Guidelines Arch Intern Med, January 13, 2003; 163(1): 33 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Engelhart, M. I. Geerlings, A. Ruitenberg, J. C. van Swieten, A. Hofman, J. C. M. Witteman, and M. M. B. Breteler Dietary Intake of Antioxidants and Risk of Alzheimer Disease JAMA, June 26, 2002; 287(24): 3223 - 3229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. Feldman The Scientific Evidence for a Beneficial Health Relationship Between Walnuts and Coronary Heart Disease J. Nutr., May 1, 2002; 132(5): 1062S - 1101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. A. Van Hoydonck, E. H. M. Temme, and E. G. Schouten A Dietary Oxidative Balance Score of Vitamin C, {beta}-Carotene and Iron Intakes and Mortality Risk in Male Smoking Belgians J. Nutr., April 1, 2002; 132(4): 756 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Dillon, G. M. Lowe, D. Billington, and K. Rahman Dietary Supplementation with Aged Garlic Extract Reduces Plasma and Urine Concentrations of 8-Iso-Prostaglandin F2{alpha} in Smoking and Nonsmoking Men and Women J. Nutr., February 1, 2002; 132(2): 168 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Franz, J. P. Bantle, C. A. Beebe, J. D. Brunzell, J.-L. Chiasson, A. Garg, L. A. Holzmeister, B. Hoogwerf, E. Mayer-Davis, A. D. Mooradian, et al. Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications Diabetes Care, January 1, 2002; 25(1): 148 - 198. [Full Text] [PDF]
|
|
|
|
|
|
K. Klipstein-Grobusch, J. H. den Breeijen, D. E. Grobbee, H. Boeing, A. Hofman, and J. C. M. Witteman Dietary Antioxidants and Peripheral Arterial Disease : The Rotterdam Study Am. J. Epidemiol., July 15, 2001; 154(2): 145 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Kritchevsky, A. J. Bush, M. Pahor, and M. D. Gross Serum Carotenoids and Markers of Inflammation in Nonsmokers Am. J. Epidemiol., December 1, 2000; 152(11): 1065 - 1071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Feki, M. Souissi, E. Mokhtar, M. Hsairi, N. Kaabachi, H. Antebi, L. G. Alcindor, R. Mechmeche, and A. Mebazaa Vitamin E and Coronary Heart Disease in Tunisians Clin. Chem., September 1, 2000; 46(9): 1401 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Halliwell Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward? Cardiovasc Res, August 18, 2000; 47(3): 410 - 418. [Full Text] [PDF]
|
|
|
|
 |
|
 The Heart Outcomes Prevention Evaluation Study Inv Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients N. Engl. J. Med., January 20, 2000; 342(3): 154 - 160. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
