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Serum carotenoids and tocopherols and incidence of age-related nuclear cataract^1,2,3

See related article on page 237.

Background: It is not known whether the protective effects of antioxidants on cataract observed in experimental animals are relevant to age-related opacities in humans.

Objective: The relations of serum carotenoids and tocopherols to the incidence of age-related nuclear cataract were investigated in a random sample of 400 adults, 50–86 y of age, in the Beaver Dam Eye Study.

Design: Nuclear opacity was assessed by using lens photographs taken at baseline (in 1988–1990) and follow-up (in 1993–1995). Nonfasting concentrations of individual carotenoids and - and -tocopherol, were determined from serum obtained at baseline. A total of 252 persons were eligible for incident cataract, of whom 57 developed nuclear cataract in at least one eye. Results were adjusted for age, smoking, serum cholesterol, heavy drinking, adiposity, and, in the tocopherol models, dietary linoleic acid intake.

Results: Only serum tocopherol (the sum of - and -tocopherol, in µmol/mmol cholesterol) was associated with cataract. For total serum tocopherol, persons in tertile 3 had a lower risk of cataract than persons in tertile 1 [odds ratio (OR): 0.4; 95% CI: 0.2, 0.9; P = 0.03 for linear trend]. Although serum carotenoids were not significantly associated with nuclear cataract, marginal inverse associations with lutein (OR: 0.3; 95% CI: 0.1, 1.2; P = 0.13 for linear trend) and cryptoxanthin (OR: 0.3; 95% CI: 0.1, 1.3; P = 0.11 for linear trend) were suggested in people 65 y of age.

Conclusions: Findings were compatible with the possibility that nuclear cataract may be linked inversely to vitamin E status, but neither strongly supported nor negated the hypothesized inverse association of nuclear cataract with serum carotenoids.

Key Words: Serum carotenoids • serum tocopherols • humans • aging • nuclear cataract • vitamin E status • Beaver Dam Eye Study

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