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American Journal of Clinical Nutrition, Vol. 69, No. 3, 544-548, March 1999
© 1999 American Society for Clinical Nutrition


Original Research Communications

Oligofructose stimulates calcium absorption in adolescents1,2,3

Ellen GHM van den Heuvel, Theo Muys, Wim van Dokkum and Gertjan Schaafsma

Background: In rats, nondigestible oligosaccharides stimulate calcium absorption. Recently, this effect was also found in human subjects.

Objective: The objective of the study was to investigate whether consumption of 15 g oligofructose/d stimulates calcium absorption in male adolescents.

Design: Twelve healthy, male adolescents aged 14–16 y received, for 9 d, 15 g oligofructose or sucrose (control treatment) daily over 3 main meals. The treatments were given according to a randomized, double-blind, crossover design, separated by a 19-d washout period. On the 8th day of each treatment period, 44Ca was given orally with a standard breakfast containing {approx}200 mg Ca. Within half an hour after administration of 44Ca, 48Ca was administered intravenously. Fractional calcium absorption was computed from the enrichment of 44Ca:43Ca and 48Ca:43Ca in 36-h urine samples, which was measured by inductively coupled plasma mass spectrometry.

Results: An increase in true fractional calcium absorption (%) was found after consumption of oligofructose (mean difference ± SE of difference: 10.8 ± 5.6; P < 0.05, one sided). The results are discussed in relation to the methods used.

Conclusion: Fifteen grams of oligofructose per day stimulates fractional calcium absorption in male adolescents.

Key Words: Oligofructose • true calcium absorption • male adolescents • double stable-isotope technique • nondigestible oligosaccharides




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