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American Journal of Clinical Nutrition, Vol. 69, No. 5, 1046S-1051S, May 1999
© 1999 American Society for Clinical Nutrition

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Influences of microbiota on intestinal immune system development1,2,3

John J Cebra

The normal colonization of the mammalian intestine with commensal microbes is hypothesized to drive the development of the humoral and cellular mucosal immune systems during neonatal life and to maintain the physiologically normal steady state of inflammation in the gut throughout life. Neonatal conventionally reared mice and germ-free, deliberately colonized adult mice (gnotobiotic mice) were used to examine the efficacy of certain intestinal microbes.

Key Words: Gut flora • intestinal microbes • mucosal immune system • development of immunity • enteric viruses • bacterial gut commensals • colonization resistance • humoral mucosal immunity • cellular mucosal immunity • mice




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