HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Teuri, U. Articles by Korpela, R. Search for Related Content PubMed PubMed Citation Articles by Teuri, U. Articles by Korpela, R. Agricola Articles by Teuri, U. Articles by Korpela, R.

Fructooligosaccharides and lactulose cause more symptoms in lactose maldigesters and subjects with pseudohypolactasia than in control lactose digesters^1,2

Background: Many lactose maldigesters tolerate more lactose in experimental studies than in everyday life, in which their symptoms may result from other carbohydrates as well.

Objective: The question of whether the symptoms caused by large quantities of carbohydrates are more severe in lactose maldigesters than in control lactose digesters or in lactose digesters who report milk to be the cause of their gastrointestinal symptoms (pseudohypolactasic subjects) was studied in a randomized, double-blind, crossover study. Comparisons between commonly used diagnostic methods for lactose maldigestion were also made.

Design: The subjects were 40 women aged 20–63 y from 3 groups: lactose maldigesters (n = 12), pseudohypolactasic subjects (n = 15), and control lactose digesters (n = 13). The subjects were given either 50 g lactose, 50 g sucrose, 25 g lactulose, or 25 g fructooligosaccharides. After carbohydrate ingestion, urine was collected and the breath-hydrogen concentration was measured every 30 min for 3 h. Blood glucose was measured every 20 min for 1 h and subjective gastrointestinal symptoms were monitored for 8 h with a questionnaire.

Results: When lactulose and fructooligosaccharides were ingested, the lactose maldigesters (P = 0.04 and 0.09, respectively) and the pseudohypolactasic subjects (P = 0.006 and 0.01, respectively) reported more symptoms than did the control lactose digesters. Sucrose caused more symptoms in the lactose maldigesters than in the control lactose digesters (P = 0.05).

Conclusions: Lactose maldigesters and lactose digesters with pseudohypolactasia experience more symptoms than control lactose digesters after a single intake of large amounts of indigestible carbohydrates. Lactose maldigesters also experience more symptoms after ingesting sucrose.

Key Words: Breath-hydrogen test • fructooligosaccharides • galactose • gastrointestinal symptoms • pseudohypolactasia • lactose • lactose intolerance • lactulose • sucrose • women • Finland

This article has been cited by other articles:

				D. A. Savaiano, C. J. Boushey, and G. P. McCabe Lactose Intolerance Symptoms Assessed by Meta-Analysis: A Grain of Truth That Leads to Exaggeration J. Nutr., April 1, 2006; 136(4): 1107 - 1113. [Abstract] [Full Text] [PDF]

				M. Olesen and E. Gudmand-Hoyer Efficacy, safety, and tolerability of fructooligosaccharides in the treatment of irritable bowel syndrome Am. J. Clinical Nutrition, December 1, 2000; 72(6): 1570 - 1575. [Abstract] [Full Text] [PDF]

				T. H. Vesa, P. Marteau, and R. Korpela Lactose Intolerance J. Am. Coll. Nutr., April 1, 2000; 19(90002): 165S - 175. [Abstract] [Full Text] [PDF]

				K. Peuhkuri, H. Vapaatalo, R. Korpela, and U. Teuri Lactose intolerance--a confusing clinical diagnosis Am. J. Clinical Nutrition, February 1, 2000; 71(2): 600 - 602. [Full Text] [PDF]