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American Journal of Clinical Nutrition, Vol 7, 80-85, Copyright © 1959 by The American Society for Clinical Nutrition, Inc.

Hypoglycemic Effects of Saccharin in Experimental Animals

MARILYN M. THOMPSON 1 and JEAN MAYER PH.D., D.SC.1

1 From the Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

A study was made of both chronic and acute administration of saccharin to obese-hyperglycemic mice, their lean littermates, and adult female Wistar rats. Hypoglycemia was produced in obese-hyperglycemic mice following chronic administration of 125-175 mg saccharin daily; no change in blood sugar was seen in the other animals.

Acute intraperitoneal injection of 100 mg and 10 mg saccharin to fed rats and to the fed mice, respectively, was also effective in lowering the blood sugar. There was no reduction when the same doses were injected into fasted animals or when administration was by stomach tube.






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Copyright © 1959 by The American Society for Nutrition