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American Journal of Clinical Nutrition, Vol 7, 251-258, Copyright © 1959 by The American Society for Clinical Nutrition, Inc.

The Etiology of Phrynoderma

Histologic Evidence

KALYAN BAGCHI B.SC., M.B.B.S., PH.D.1, K. HALDER M.B.B.S.1, and S. R. CHOWDHURY M.SC., D.PHIL.1

1 From the Department of Biochemistry and Nutrition, All-India Institute of Hygiene and Public Health, Calcutta, India

Clinical, biochemical, and histologic investigations were carried out on selected well-established cases of phrynoderma. The therapeutic effects of essential fatty acids in the form of raw linseed oil and linoleic acid were observed. Biochemical and histologic changes as a result of this therapy were studied. The significant role of essential fatty acids in the etiology of phrynoderma in human subjects has been discussed in the light of these evidences, and it is concluded that phrynoderma is a manifestation of essential-fatty-acid deficiency in man.






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Copyright © 1959 by The American Society for Nutrition