AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by RUNDLES, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by RUNDLES, R. W.
Agricola
Right arrow Articles by RUNDLES, R. W.

American Journal of Clinical Nutrition, Vol 7, 385-389, Copyright © 1959 by The American Society for Clinical Nutrition, Inc.

Hematopoietic Effects of Folic Acid Metabolites in the Megaloblastic Anemias

R. WAYNE RUNDLES M.D.1

1 From the Department of Medicine, Duke University School of Medicine, and the Hematology Laboratory, Duke Hospital, Durham, North Carolina

Folic acid functions as a coenzyme in the biosynthesis of three amino acids, serine, histidine, and methionine, the purine ring and thymine. The major clinical manifestation of folic acid deficiency is megaloblastic anemia, presumably due to a lack of these "essential" metabolites.

The hematopoietic effect of folic acid metabolites when administered singly and in combination to patients with megaloblastic anemia has been studied. Significant but usually suboptimal responses have been obtained so far with serine, histidine, inosine, and thymidine.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1959 by The American Society for Nutrition