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American Journal of Clinical Nutrition, Vol 7, 397-406, Copyright © 1959 by The American Society for Clinical Nutrition, Inc.

Urinary Excretion of Formiminoglutamic Acid

Application in Diagnosis of Clinical Folic Acid Deficiency

A. LEONARD LUHBY M.D.1, JACK M. COOPERMAN PH.D.1, and DAVID N. TELLER B.S.1

1 From the Hematology and Nutrition Laboratory, Department of Pediatrics, New York Medical College, New York City

Folic acid deficiency results in inability to degrade a formiminoglutamic acid (FIGLU) to glutamic acid so that FIGLU accumulates in excessive amounts and is excreted in the urine.

The assay technics which have been developed for detection of FIGLU are described and evaluated.

Increased urinary FIGLU following an oral histidine monohydrochloride metabolic load of 15 g daily for two to three days is a biochemical index of folic acid deficiency. It is proposed as a new test to differentiate clinical folic acid deficiency states from those due to deficiency of vitamin B12, such as addisonian pernicious anemia.




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J. M. Cooperman and R. Lopez
The Role of Histidine in the Anemia of Folate Deficiency
Experimental Biology and Medicine, December 1, 2002; 227(11): 998 - 1000.
[Abstract] [Full Text]


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