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American Journal of Clinical Nutrition, Vol 7, 721-725, Copyright © 1959 by The American Society for Clinical Nutrition, Inc.

Amino-Aciduria in a Case of Scurvy

J. M. CHADWICK M.B., CH.B.1, J. S. FAWCETT M.B., B.S.1, and F. G. WARBURTON B.SC.(LOND.), A.R.I.C., A.M.C.T.1

1 From the Department of Pathology, Hope Hospital, Salford, England

A case of "bachelor scurvy" is described in which the patient is in an advanced state of vitamin C deficiency.

An attempt was made to determine the presence of amino-aciduria, and it was found that this case was not markedly different from those already described. During the period when haematoma was being resolved the amino-aciduria increased. Increased excretion of threonine and glycine was particularly well marked.

This patient responded almost dramatically to treatment, and the rapid physical changes were reflected by the extent of the amino-aciduria. The return to a normal amino acid excretion was only a matter of about one week, as compared to three weeks reported in children.

A simple method for one-dimensional chromatography is given, by which it was possible to follow the course of the amino-aciduria.






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Copyright © 1959 by The American Society for Nutrition