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Original Research Communications |
1 From the Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta.
Background: Previous studies suggested that diabetes mellitus may lower serum vitamin C concentrations, but most of these studies used clinic-based populations with established diabetes of varying duration and did not adjust for important covariates.
Objective: Using a population-based sample and adjusting for important covariates, we asked whether serum vitamin C concentrations in persons with newly diagnosed diabetes differed from those in persons without diabetes.
Design: Data were obtained from the third National Health and Nutrition Examination Survey (1988–1994). Serum vitamin C was assayed by using reversed-phase HPLC with multiwavelength detection. Diabetes status (n = 237 persons with diabetes; n = 1803 persons without diabetes) was determined by oral-glucose-tolerance testing of the sample aged 40–74 y.
Results: After adjustment for age and sex, mean serum vitamin C concentrations were significantly lower in persons with newly diagnosed diabetes than in those without diabetes. After adjustment for dietary intake of vitamin C and other important covariates, however, mean concentrations did not differ according to diabetes status.
Conclusion: When assessing serum vitamin C concentrations by diabetes status in the future, researchers should measure and account for all factors that influence serum vitamin C concentrations.
Key Words: Ascorbic acid • blood chemical analysis • diabetes mellitus • diet surveys • epidemiology • population • NHANES III • vitamin C • oral-glucose-tolerance test • third National Health and Nutrition Examination Survey
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