| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communications |
1 From the Veterans Affairs Medical Center, the University of Kentucky, Lexington, and The Procter & Gamble Company, Cincinnati.
Background: Water-soluble dietary fibers decrease postprandial glucose concentrations and decrease serum cholesterol concentrations. This study examined the effects of administering psyllium to men with type 2 diabetes.
Objective: The objective was to evaluate the safety and effectiveness of psyllium husk fiber used adjunctively to a traditional diet for diabetes in the treatment of men with type 2 diabetes and mild-to-moderate hypercholesterolemia.
Design: After a 2-wk dietary stabilization phase, 34 men with type 2 diabetes and mild-to-moderate hypercholesterolemia were randomly assigned to receive 5.1 g psyllium or cellulose placebo twice daily for 8 wk. Serum lipid and glycemic indexes were evaluated biweekly on an outpatient basis and at weeks 0 and 8 in a metabolic ward.
Results: In the metabolic ward, the psyllium group showed significant improvements in glucose and lipid values compared with the placebo group. Serum total and LDL-cholesterol concentrations were 8.9% (P < 0.05) and 13.0% (P = 0.07) lower, respectively, in the psyllium than in the placebo group. All-day and postlunch postprandial glucose concentrations were 11.0% (P < 0.05) and 19.2% (P < 0.01) lower in the psyllium than in the placebo group. Both products were well tolerated, with no serious adverse events related to treatment reported in either group.
Conclusion: The addition of psyllium to a traditional diet for persons with diabetes is safe, is well tolerated, and improves glycemic and lipid control in men with type 2 diabetes and hypercholesterolemia.
Key Words: Psyllium • type 2 diabetes • serum lipids • hypercholesterolemia • postprandial glucose • glycemic response • fiber • men
This article has been cited by other articles:
|
|
 |
|
  M. Galisteo, M. Sanchez, R. Vera, M. Gonzalez, A. Anguera, J. Duarte, and A. Zarzuelo A Diet Supplemented with Husks of Plantago ovata Reduces the Development of Endothelial Dysfunction, Hypertension, and Obesity by Affecting Adiponectin and TNF-{alpha} in Obese Zucker Rats J. Nutr., October 1, 2005; 135(10): 2399 - 2404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. A Castro, L. P Barroso, and P. Sinnecker Functional foods for coronary heart disease risk reduction: a meta-analysis using a multivariate approach Am. J. Clinical Nutrition, July 1, 2005; 82(1): 32 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Anderson, K. M. Randles, C. W. C. Kendall, and D. J. A. Jenkins Carbohydrate and Fiber Recommendations for Individuals with Diabetes: A Quantitative Assessment and Meta-Analysis of the Evidence J. Am. Coll. Nutr., February 1, 2004; 23(1): 5 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Jenkins, C. W. Kendall, A. Marchie, A. L Jenkins, L. S. Augustin, D. S Ludwig, N. D Barnard, and J. W Anderson Type 2 diabetes and the vegetarian diet Am. J. Clinical Nutrition, September 1, 2003; 78(3): 610S - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Romero, K. L. West, T. Zern, and M. L. Fernandez The Seeds from Plantago ovata Lower Plasma Lipids by Altering Hepatic and Bile Acid Metabolism in Guinea Pigs J. Nutr., June 1, 2002; 132(6): 1194 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Franz, J. P. Bantle, C. A. Beebe, J. D. Brunzell, J.-L. Chiasson, A. Garg, L. A. Holzmeister, B. Hoogwerf, E. Mayer-Davis, A. D. Mooradian, et al. Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications Diabetes Care, January 1, 2002; 25(1): 148 - 198. [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Bell and J. Shabert Nutritional Modulation of Blood Parameters in Type 2 Diabetes The Diabetes Educator, May 1, 2001; 27(3): 368 - 375. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
