| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communications |
1 From the Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst; the Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston; the Departments of Epidemiology, Nutrition, and Biostatistics, Harvard School of Public Health, Boston; and Department of Ophthalmology, Harvard Medical School, Boston, and Massachusetts Eye and Ear Infirmary.
Background: Oxidation of lens proteins plays a central role in the formation of age-related cataracts, suggesting that dietary antioxidants may play a role in prevention. However, the relation between specific antioxidants and risk of cataract remains uncertain.
Objective: Our objective was to examine prospectively the association between carotenoid and vitamin A intakes and cataract extraction in women.
Methods: A prospective cohort of registered female nurses aged 45–71 y and free of diagnosed cancer was followed; in 1980, 50461 were included and others were added as they became 45 y of age for a total of 77466. Information on nutrient intake was assessed by repeated administration of a food-frequency questionnaire during 12 y of follow-up.
Results: During 761762 person-years of follow-up, 1471 cataracts were extracted. After age, smoking, and other potential cataract risk factors were controlled for, those with the highest intake of lutein and zeaxanthin had a 22% decreased risk of cataract extraction compared with those in the lowest quintile (relative risk: 0.78; 95% CI: 0.63, 0.95; P for trend = 0.04). Other carotenoids (
-carotene, ß-carotene, lycopene, and ß-cryptoxanthin), vitamin A, and retinol were not associated with cataract in multivariate analysis. Increasing frequency of intakes of spinach and kale, foods rich in lutein, was associated with a moderate decrease in risk of cataract.
Conclusions: Lutein and zeaxanthin and foods rich in these carotenoids may decrease the risk of cataracts severe enough to require extraction.
Key Words: Cataract • cataract extraction • diet • women • prospective studies • vitamin A • carotene • lutein • zeaxanthin • carotenoids • Nurses' Health Study • food-frequency questionnaire
This article has been cited by other articles:
|
|
 |
|
  S. Sahni, M. T Hannan, J. Blumberg, L A. Cupples, D. P Kiel, and K. L Tucker Inverse association of carotenoid intakes with 4-y change in bone mineral density in elderly men and women: the Framingham Osteoporosis Study Am. J. Clinical Nutrition, January 1, 2009; 89(1): 416 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dherani, G. V. S. Murthy, S. K. Gupta, I. S. Young, G. Maraini, M. Camparini, G. M. Price, N. John, U. Chakravarthy, and A. E. Fletcher Blood Levels of Vitamin C, Carotenoids and Retinol Are Inversely Associated with Cataract in a North Indian Population Invest. Ophthalmol. Vis. Sci., August 1, 2008; 49(8): 3328 - 3335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Moeller, R. Voland, L. Tinker, B. A. Blodi, M. L. Klein, K. M. Gehrs, E. J. Johnson, D. M. Snodderly, R. B. Wallace, R. J. Chappell, et al. Associations Between Age-Related Nuclear Cataract and Lutein and Zeaxanthin in the Diet and Serum in the Carotenoids in the Age-Related Eye Disease Study (CAREDS), an Ancillary Study of the Women's Health Initiative Arch Ophthalmol, March 1, 2008; 126(3): 354 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Christen, S. Liu, R. J. Glynn, J. M. Gaziano, and J. E. Buring Dietary Carotenoids, Vitamins C and E, and Risk of Cataract in Women: A Prospective Study Arch Ophthalmol, January 1, 2008; 126(1): 102 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M Seddon Multivitamin-multimineral supplements and eye disease: age-related macular degeneration and cataract Am. J. Clinical Nutrition, January 1, 2007; 85(1): 304S - 307S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R Trumbo and K. C Ellwood Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. Am. J. Clinical Nutrition, November 1, 2006; 84(5): 971 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. V. Vu, L. Robman, A. Hodge, C. A. McCarty, and H. R. Taylor Lutein and zeaxanthin and the risk of cataract: the melbourne visual impairment project. Invest. Ophthalmol. Vis. Sci., September 1, 2006; 47(9): 3783 - 3786. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D C Gritz, M Srinivasan, S D Smith, U Kim, T M Lietman, J H Wilkins, B Priyadharshini, R K John, S Aravind, N V Prajna, et al. The Antioxidants in Prevention of Cataracts Study: effects of antioxidant supplements on cataract progression in South India Br. J. Ophthalmol., July 1, 2006; 90(7): 847 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Delcourt, I. Carriere, M. Delage, P. Barberger-Gateau, W. Schalch, and the POLA Study Group Plasma Lutein and Zeaxanthin and Other Carotenoids as Modifiable Risk Factors for Age-Related Maculopathy and Cataract: The POLA Study. Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2329 - 2335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Bischoff, H. B. Staehelin, and W. C. Willett The effect of undernutrition in the development of frailty in older persons. J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2006; 61(6): 585 - 589. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chitchumroonchokchai and M. L. Failla Hydrolysis of Zeaxanthin Esters by Carboxyl Ester Lipase during Digestion Facilitates Micellarization and Uptake of the Xanthophyll by Caco-2 Human Intestinal Cells J. Nutr., March 1, 2006; 136(3): 588 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. N. Mukesh, A. Le, P. N. Dimitrov, S. Ahmed, H. R. Taylor, and C. A. McCarty Development of Cataract and Associated Risk Factors: The Visual Impairment Project Arch Ophthalmol, January 1, 2006; 124(1): 79 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Santosa and P. J.H. Jones Oxidative stress in ocular disease: Does lutein play a protective role? Can. Med. Assoc. J., October 11, 2005; 173(8): 861 - 862. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Wang, H. Zhu, H. Sun, J. Pan, Z. Yuan, and R. Yu Plasma 8-Isoprostane Concentrations in Patients with Age-Related Cataracts Clin. Chem., August 1, 2005; 51(8): 1541 - 1544. [Full Text] [PDF]
|
|
|
|
|
|
P. A Thurmann, W. Schalch, J.-C. Aebischer, U. Tenter, and W. Cohn Plasma kinetics of lutein, zeaxanthin, and 3-dehydro-lutein after multiple oral doses of a lutein supplement Am. J. Clinical Nutrition, July 1, 2005; 82(1): 88 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G Christen, S. Liu, D. A Schaumberg, and J. E Buring Fruit and vegetable intake and the risk of cataract in women Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1417 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. Jacques, A. Taylor, S. Moeller, S. E. Hankinson, G. Rogers, W. Tung, J. Ludovico, W. C. Willett, and L. T. Chylack Jr Long-term Nutrient Intake and 5-Year Change in Nuclear Lens Opacities Arch Ophthalmol, April 1, 2005; 123(4): 517 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Umeno, A. V. Tobias, and F. H. Arnold Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution Microbiol. Mol. Biol. Rev., March 1, 2005; 69(1): 51 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chitchumroonchokchai, J. A. Bomser, J. E. Glamm, and M. L. Failla Xanthophylls and {alpha}-Tocopherol Decrease UVB-Induced Lipid Peroxidation and Stress Signaling in Human Lens Epithelial Cells J. Nutr., December 1, 2004; 134(12): 3225 - 3232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Ribaya-Mercado and J. B. Blumberg Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 567S - 587S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Moeller, A. Taylor, K. L. Tucker, M. L. McCullough, L. T. Chylack Jr, S. E. Hankinson, W. C. Willett, and P. F. Jacques Overall Adherence to the Dietary Guidelines for Americans Is Associated with Reduced Prevalence of Early Age-Related Nuclear Lens Opacities in Women J. Nutr., July 1, 2004; 134(7): 1812 - 1819. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Rowe, C. H. MacLean, and P. G. Shekelle Preventing Visual Loss From Chronic Eye Disease in Primary Care: Scientific Review JAMA, March 24, 2004; 291(12): 1487 - 1495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Kang, L. R. Pasquale, W. Willett, B. Rosner, K. M. Egan, N. Faberowski, and S. E. Hankinson Antioxidant Intake and Primary Open-Angle Glaucoma: A Prospective Study Am. J. Epidemiol., August 15, 2003; 158(4): 337 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H Halsted Dietary supplements and functional foods: 2 sides of a coin? Am. J. Clinical Nutrition, April 1, 2003; 77(4): 1001S - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Christen, J. E. Manson, R. J. Glynn, J. M. Gaziano, R. D. Sperduto, J. E. Buring, and C. H. Hennekens A Randomized Trial of Beta Carotene and Age-Related Cataract in US Physicians Arch Ophthalmol, March 1, 2003; 121(3): 372 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. J. M. Berendschot, W. M. R. Broekmans, I. A. A. Klopping-Ketelaars, A. F. M. Kardinaal, G. van Poppel, and D. van Norren Lens Aging in Relation to Nutritional Determinants and Possible Risk Factors for Age-Related Cataract Arch Ophthalmol, December 1, 2002; 120(12): 1732 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Hasler Functional Foods: Benefits, Concerns and Challenges--A Position Paper from the American Council on Science and Health J. Nutr., December 1, 2002; 132(12): 3772 - 3781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Thomson, Y. Toyoda, A. Langner, F. C. Delori, K. M. Garnett, N. Craft, C. R. Nichols, K. M. Cheng, and C. K. Dorey Elevated Retinal Zeaxanthin and Prevention of Light-Induced Photoreceptor Cell Death in Quail Invest. Ophthalmol. Vis. Sci., November 1, 2002; 43(11): 3538 - 3549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Taylor, P. F Jacques, L. T Chylack Jr, S. E Hankinson, P. M Khu, G. Rogers, J. Friend, W. Tung, J. K Wolfe, N. Padhye, et al. Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities Am. J. Clinical Nutrition, March 1, 2002; 75(3): 540 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Mares-Perlman, A. E. Millen, T. L. Ficek, and S. E. Hankinson The Body of Evidence to Support a Protective Role for Lutein and Zeaxanthin in Delaying Chronic Disease. Overview J. Nutr., March 1, 2002; 132(3): 518S - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Rock, M. D. Thornquist, M. L. Neuhouser, A. R. Kristal, D. Neumark-Sztainer, D. A. Cooper, R. E. Patterson, and L. J. Cheskin Diet and Lifestyle Correlates of Lutein in the Blood and Diet J. Nutr., March 1, 2002; 132(3): 525S - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Hammond Jr, T. A. Ciulla, and D. M. Snodderly Macular Pigment Density Is Reduced in Obese Subjects Invest. Ophthalmol. Vis. Sci., January 1, 2002; 43(1): 47 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. P. Davies and A. B. Morland Color Matching in Diabetes: Optical Density of the Crystalline Lens and Macular Pigments Invest. Ophthalmol. Vis. Sci., January 1, 2002; 43(1): 281 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Weintraub, W. C. Willett, B. Rosner, G. A. Colditz, J. M. Seddon, and S. E. Hankinson Smoking Cessation and Risk of Cataract Extraction among US Women and Men Am. J. Epidemiol., January 1, 2002; 155(1): 72 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Age-Related Eye Disease Study Research Group A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E and Beta Carotene for Age-Related Cataract and Vision Loss: AREDS Report No. 9 Arch Ophthalmol, October 1, 2001; 119(10): 1439 - 1452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. Jacques, L. T. Chylack Jr, S. E. Hankinson, P. M. Khu, G. Rogers, J. Friend, W. Tung, J. K. Wolfe, N. Padhye, W. C. Willett, et al. Long-term Nutrient Intake and Early Age-Related Nuclear Lens Opacities Arch Ophthalmol, July 1, 2001; 119(7): 1009 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Dwyer, M. Navab, K. M. Dwyer, K. Hassan, P. Sun, A. Shircore, S. Hama-Levy, G. Hough, X. Wang, T. Drake, et al. Oxygenated Carotenoid Lutein and Progression of Early Atherosclerosis : The Los Angeles Atherosclerosis Study Circulation, June 19, 2001; 103(24): 2922 - 2927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Ciulla, B. R. Hammond Jr, C. W. Yung, and L. M. Pratt Macular Pigment Optical Density before and after Cataract Extraction Invest. Ophthalmol. Vis. Sci., May 1, 2001; 42(6): 1338 - 1341. [Abstract] [Full Text]
|
|
|
|
|
|
D. A Schaumberg, R. J Glynn, W. G Christen, S. E Hankinson, and C. H Hennekens Relations of body fat distribution and height with cataract in men Am. J. Clinical Nutrition, December 1, 2000; 72(6): 1495 - 1502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Hasler The Changing Face of Functional Foods J. Am. Coll. Nutr., October 1, 2000; 19(90005): 499S - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Moeller, P. F. Jacques, and J. B. Blumberg The Potential Role of Dietary Xanthophylls in Cataract and Age-Related Macular Degeneration J. Am. Coll. Nutr., October 1, 2000; 19(90005): 522S - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A Mares-Perlman Too soon for lutein supplements Am. J. Clinical Nutrition, October 1, 1999; 70(4): 431 - 432. [Full Text] [PDF]
|
|
|
|
|
|
L. Brown, E. B Rimm, J. M Seddon, E. L Giovannucci, L. Chasan-Taber, D. Spiegelman, W. C Willett, and S. E Hankinson A prospective study of carotenoid intake and risk of cataract extraction in US men Am. J. Clinical Nutrition, October 1, 1999; 70(4): 517 - 524. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
