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Report of a Meeting |
1 From the Division of Nutritional Sciences and the Institute for Cellular and Molecular Biology, The University of Texas at Austin.
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription factors that belong to the steroid receptor superfamily. This family of PPARs includes PPAR
, PPAR
, PPAR
1, and PPAR2. These PPARs are related to the T3 and vitamin D3 receptors and bind to a hexameric direct repeat as a heterodimeric complex with retinoid receptor X. PPARs regulate the expression of a wide array of genes that encode proteins involved in lipid metabolism, energy balance, eicosanoid signaling, cell differentiation, and tumorigenesis. A unique feature of these steroid-like receptors is that the physiologic ligands for PPARs appear to be fatty acids from the n-6 and n-3 families of fatty acids and their respective eicosanoid products. This review describes the characteristics, regulation, and gene targets for PPARs and relates their effects on gene expression to physiologic outcomes that affect lipid and glucose metabolism, thermogenesis, atherosclerosis, and cell differentiation.
Key Words: Peroxisome proliferator-activated receptor • fat cells • differentiation • fatty acids • fatty acid synthase • transcription factor • retinoid receptor X • review
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