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Original Research Communications |
1 From the Graduate Program in Nutrition, The Pennsylvania State University, University Park, and the Department of Community and Preventive Medicine, University of Rochester Medical Center, Rochester, NY.
Background: Low-fat diets increase plasma triacylglycerol and decrease HDL-cholesterol concentrations, thereby potentially adversely affecting cardiovascular disease (CVD) risk. High–monounsaturated fatty acid (MUFA), cholesterol-lowering diets do not raise triacylglycerol or lower HDL cholesterol, but little is known about how peanut products, a rich source of MUFAs, affect CVD risk.
Objective: The present study compared the CVD risk profile of an Average American diet (AAD) with those of 4 cholesterol-lowering diets: an American Heart Association/National Cholesterol Education Program Step II diet and 3 high-MUFA diets [olive oil (OO), peanut oil (PO), and peanuts and peanut butter (PPB)].
Design: A randomized, double-blind, 5-period crossover study design (n = 22) was used to examine the effects of the diets on serum lipids and lipoproteins: AAD [34% fat; 16% saturated fatty acids (SFAs), 11% MUFAs], Step II (25% fat; 7% SFAs, 12% MUFAs), OO (34% fat; 7% SFAs, 21% MUFAs), PO (34% fat; 7% SFAs, 17% MUFAs), and PPB (36% fat; 8% SFAs, 18% MUFAs).
Results: The high-MUFA diets lowered total cholesterol by 10% and LDL cholesterol by 14%. This response was comparable with that observed for the Step II diet. Triacylglycerol concentrations were 13% lower in subjects consuming the high-MUFA diets and were 11% higher with the Step II diet than with the AAD. The high-MUFA diets did not lower HDL cholesterol whereas the Step II diet lowered it by 4% compared with the AAD. The OO, PO, and PPB diets decreased CVD risk by an estimated 25%, 16%, and 21%, respectively, whereas the Step II diet lowered CVD risk by 12%.
Conclusion: A high-MUFA, cholesterol-lowering diet may be preferable to a low-fat diet because of more favorable effects on the CVD risk profile.
Key Words: Plasma triacylglycerol • HDL cholesterol • LDL cholesterol • monounsaturated fatty acids • dietary fat • peanuts • peanut products • Step II diet • cardiovascular disease • humans
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|
|
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|
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|
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|
|
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|
|
|
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|
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|
|
|
|
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|
|
|
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|
|
|
|
 |
|
 References Circulation, December 17, 2002; 106(25): 3373 - 3421. [Full Text]
|
|
|
|
|
|
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|
|
|
|
 |
|
 E. R. Miller 3rd, T. P. Erlinger, D. R. Young, M. Jehn, J. Charleston, D. Rhodes, S. K. Wasan, and L. J. Appel Results of the Diet, Exercise, and Weight Loss Intervention Trial (DEW-IT) Hypertension, November 1, 2002; 40(5): 612 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
T. Gulesserian and K. Widhalm Effect of a Rapeseed Oil Substituting Diet on Serum Lipids and Lipoproteins in Children and Adolescents with Familial Hypercholesterolemia J. Am. Coll. Nutr., April 1, 2002; 21(2): 103 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Hyson, B. O. Schneeman, and P. A. Davis Almonds and Almond Oil Have Similar Effects on Plasma Lipids and LDL Oxidation in Healthy Men and Women J. Nutr., April 1, 2002; 132(4): 703 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Tittelbach and R. D. Mattes Oral Stimulation Influences Postprandial Triacylglycerol Concentrations in Humans: Nutrient Specificity J. Am. Coll. Nutr., October 1, 2001; 20(5): 485 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rajaram, K. Burke, B. Connell, T. Myint, and J. Sabate A Monounsaturated Fatty Acid-Rich Pecan-Enriched Diet Favorably Alters the Serum Lipid Profile of Healthy Men and Women J. Nutr., September 1, 2001; 131(9): 2275 - 2279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. U Almario, V. Vonghavaravat, R. Wong, and S. E Kasim-Karakas Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia Am. J. Clinical Nutrition, July 1, 2001; 74(1): 72 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 R. M. Krauss, R. H. Eckel, B. Howard, L. J. Appel, S. R. Daniels, R. J. Deckelbaum, J. W. Erdman Jr, P. Kris-Etherton, I. J. Goldberg, T. A. Kotchen, et al. AHA Dietary Guidelines : Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association Stroke, November 1, 2000; 31(11): 2751 - 2766. [Full Text] [PDF]
|
|
|
|
|
|
R. M. Krauss, R. H. Eckel, B. Howard, L. J. Appel, S. R. Daniels, R. J. Deckelbaum, J. W. Erdman Jr, P. Kris-Etherton, I. J. Goldberg, T. A. Kotchen, et al. AHA Dietary Guidelines : Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association Circulation, October 31, 2000; 102(18): 2284 - 2299. [Full Text] [PDF]
|
|
|
|
|
|
F. Visioli and C. Galli Olive oil: more than just oleic acid Am. J. Clinical Nutrition, September 1, 2000; 72(3): 853 - 853. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
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|
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|
|
|
|
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|
|
|
|
|
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E. B Feldman Assorted monounsaturated fatty acids promote healthy hearts Am. J. Clinical Nutrition, December 1, 1999; 70(6): 953 - 954. [Full Text] [PDF]
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