HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jackson, K. G Articles by Williams, C. M Search for Related Content PubMed PubMed Citation Articles by Jackson, K. G Articles by Williams, C. M Agricola Articles by Jackson, K. G Articles by Williams, C. M

Differences in glucose-dependent insulinotrophic polypeptide hormone and hepatic lipase in subjects of southern and northern Europe: implications for postprandial lipemia^1,2,3

¹ From the Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, United Kingdom; the Department of Clinical Medicine, Trinity College, St James's Hospital, Dublin; and the Department of Social and Preventative Medicine, University of Crete School of Medicine, Greece.

Background: This study was an extension of a previous study that showed different lipemic responses to standard test meals in subjects from southern and northern Europe.

Objective: The aim was to determine in 32 healthy young men from northern and southern Europe whether differences in the secretion of insulin and glucose-dependent insulinotrophic polypeptide (GIP) might explain these findings through the actions of these hormones on lipoprotein lipase.

Design: We investigated in a randomized, single-blind, crossover study the effects of 2 test meals of identical macronutrient composition but different saturated fatty acid (SFA) and monounsaturated fatty acid (MUFA) contents on postprandial GIP, insulin, the ratio of incremental triacylglycerol to apolipoprotein B-48 (a marker of chylomicron size), and the activity of postheparin lipases.

Results: Fasting and postprandial GIP concentrations and postheparin hepatic lipase activities were significantly higher in the southern Europeans (P < 0.001 and P < 0.02, respectively). Lipoprotein lipase activity after the SFA-rich meal was significantly higher in the northern Europeans (P < 0.01). HL activity 9 h after the SFA-rich meal and the area under the curve (AUC) for the postprandial insulin response correlated with the AUC for the postprandial GIP response [r = 0.44 (P < 0.04) and r = 0.46 (P < 0.05), respectively]. There were no significant differences in chylomicron size between the 2 groups for either meal, but when the groups were combined there was a significant difference in chylomicron size between the SFA- and MUFA-rich meals (P < 0.05), which could be due to the formation of larger chylomicrons after the MUFA-rich meal.

Conclusion: The significantly higher GIP and insulin responses and HL activities in southern Europeans may provide an explanation for our previous report of attenuated postprandial triacylglycerol and apolipoprotein B-48 responses in them.

Key Words: Glucose-dependent insulinotrophic polypeptide • hepatic lipase • postprandial lipemia • apolipoprotein B-48 • Mediterranean diet • saturated fatty acids • monounsaturated fatty acids • Europe • humans

This article has been cited by other articles:

				K. G Jackson, M D. Robertson, B. A Fielding, K. N Frayn, and C. M Williams Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed Am. J. Clinical Nutrition, November 1, 2002; 76(5): 942 - 949. [Abstract] [Full Text] [PDF]