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American Journal of Clinical Nutrition, Vol. 71, No. 1, 171S-175S, January 2000
© 2000 American Society for Clinical Nutrition

Supplements

Importance of n-3 fatty acids in health and disease1,2,3

William E Connor

1 From the Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health Sciences University, Portland.

In the past 2 decades, views about dietary n-3 fatty acids have moved from speculation about their functions to solid evidence that they are not only essential nutrients but also may favorably modulate many diseases. Docosahexaenoic acid (22:6n-3), which is a vital component of the phospholipids of cellular membranes, especially in the brain and retina, is necessary for their proper functioning. n-3 Fatty acids favorably affect atherosclerosis, coronary heart disease, inflammatory disease, and perhaps even behavioral disorders. The 38 articles in this supplement document the importance of n-3 fatty acids in both health and disease.

Key Words: n-3 Fatty acids • docosahexaenoic acid • atherosclerosis • coronary heart disease • inflammatory diseases • behavioral disorders




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Home page
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