| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communications |
1 From the University of Utah Medical School, Salt Lake City; the Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA; and the Fred Hutchinson Cancer Research Center, Seattle.
Background: Carotenoids have numerous biological properties that may underpin a role for them as chemopreventive agents. However, except for ß-carotene, little is known about how dietary carotenoids are associated with common cancers, including colon cancer.
Objective: The objective of this study was to evaluate associations between dietary 
-carotene, ß-carotene, lycopene, lutein, zeaxanthin, and ß-cryptoxanthin and the risk of colon cancer.
Design: Data were collected from 1993 case subjects with first primary incident adenocarcinoma of the colon and from 2410 population-based control subjects. Dietary data were collected from a detailed diet-history questionnaire and nutrient values for dietary carotenoids were obtained from the US Department of Agriculture–Nutrition Coordinating Center carotenoid database (1998 updated version).
Results: Lutein was inversely associated with colon cancer in both men and women [odds ratio (OR) for upper quintile of intake relative to lowest quintile of intake: 0.83; 95% CI: 0.66, 1.04; P = 0.04 for linear trend]. The greatest inverse association was observed among subjects in whom colon cancer was diagnosed when they were young (OR: 0.66; 95% CI: 0.48, 0.92; P = 0.02 for linear trend) and among those with tumors located in the proximal segment of the colon (OR: 0.65; 95% CI: 0.51, 0.91; P < 0.01 for linear trend). The associations with other carotenoids were unremarkable.
Conclusion: The major dietary sources of lutein in subjects with colon cancer and in control subjects were spinach, broccoli, lettuce, tomatoes, oranges and orange juice, carrots, celery, and greens. These data suggest that incorporating these foods into the diet may help reduce the risk of developing colon cancer.
Key Words: -Carotene • ß-carotene • ß-cryptoxanthin • carotenoids • smoking • colon cancer • lutein • lycopene • zeaxanthin • men • women
This article has been cited by other articles:
|
|
 |
|
  C. J. Kavanaugh, P. R. Trumbo, and K. C. Ellwood The U.S. Food and Drug Administration's Evidence-Based Review for Qualified Health Claims: Tomatoes, Lycopene, and Cancer J Natl Cancer Inst, July 18, 2007; 99(14): 1074 - 1085. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoshida, T. Maoka, S. K. Das, K. Kanazawa, M. Horinaka, M. Wakada, Y. Satomi, H. Nishino, and T. Sakai Halocynthiaxanthin and Peridinin Sensitize Colon Cancer Cell Lines to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mol. Cancer Res., June 1, 2007; 5(6): 615 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. I. Gill, S. Haldar, L. A Boyd, R. Bennett, J. Whiteford, M. Butler, J. R Pearson, I. Bradbury, and I. R Rowland Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults Am. J. Clinical Nutrition, February 1, 2007; 85(2): 504 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mannisto, S.-S. Yaun, D. J. Hunter, D. Spiegelman, H.-O. Adami, D. Albanes, P. A. van den Brandt, J. E. Buring, J. R. Cerhan, G. A. Colditz, et al. Dietary Carotenoids and Risk of Colorectal Cancer in a Pooled Analysis of 11 Cohort Studies Am. J. Epidemiol., February 1, 2007; 165(3): 246 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Wang, A. J. Mendy, G. Dai, H.-R. Luo, L. He, and Y.-J. Y. Wan Retinoids Activate the RXR/SXR-Mediated Pathway and Induce the Endogenous CYP3A4 Activity in Huh7 Human Hepatoma Cells Toxicol. Sci., July 1, 2006; 92(1): 51 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Porrini and P. Riso What Are Typical Lycopene Intakes? J. Nutr., August 1, 2005; 135(8): 2042S - 2045S. [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Murtaugh, K.-n. Ma, B. J. Caan, C. Sweeney, R. Wolff, W. S. Samowitz, J. D. Potter, and M. L. Slattery Interactions of Peroxisome Proliferator-Activated Receptor {gamma} and Diet in Etiology of Colorectal Cancer Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1224 - 1229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Palozza, S. Serini, N. Maggiano, G. Tringali, P. Navarra, F. O. Ranelletti, and G. Calviello {beta}-Carotene Downregulates the Steady-State and Heregulin-{alpha}-Induced COX-2 Pathways in Colon Cancer Cells J. Nutr., January 1, 2005; 135(1): 129 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Ribaya-Mercado and J. B. Blumberg Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 567S - 587S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Bogers, P. van Assema, A. D. M. Kester, K. R. Westerterp, and P. C. Dagnelie Reproducibility, Validity, and Responsiveness to Change of a Short Questionnaire for Measuring Fruit and Vegetable Intake Am. J. Epidemiol., May 1, 2004; 159(9): 900 - 909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Murtaugh, K.-n. Ma, J. Benson, K. Curtin, B. Caan, and M. L. Slattery Antioxidants, Carotenoids, and Risk of Rectal Cancer Am. J. Epidemiol., January 1, 2004; 159(1): 32 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lomnitski, E. Padilla-Banks, W. N. Jefferson, A. Nyska, S. Grossman, and R. R. Newbold A Natural Antioxidant Mixture from Spinach Does Not Have Estrogenic or Antiestrogenic Activity in Immature CD-1 Mice J. Nutr., November 1, 2003; 133(11): 3584 - 3587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Satia-Abouta, J. A. Galanko, C. F. Martin, J. D. Potter, A. Ammerman, and R. S. Sandler Associations of Micronutrients with Colon Cancer Risk in African Americans and Whites: Results from the North Carolina Colon Cancer Study Cancer Epidemiol. Biomarkers Prev., August 1, 2003; 12(8): 747 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Bogers, P. C. Dagnelie, K. R. Westerterp, A. D. M. Kester, J. D. van Klaveren, A. Bast, and P. A. van den Brandt Using a Correction Factor to Correct for Overreporting in a Food-Frequency Questionnaire Does Not Improve Biomarker-Assessed Validity of Estimates for Fruit and Vegetable Consumption J. Nutr., April 1, 2003; 133(4): 1213 - 1219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H Rissanen, S. Voutilainen, K. Nyyssonen, R. Salonen, G. A Kaplan, and J. T Salonen Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study Am. J. Clinical Nutrition, January 1, 2003; 77(1): 133 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. La Vecchia Tomatoes, Lycopene Intake, and Digestive Tract and Female Hormone-Related Neoplasms Experimental Biology and Medicine, November 1, 2002; 227(10): 860 - 863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Mares-Perlman, A. E. Millen, T. L. Ficek, and S. E. Hankinson The Body of Evidence to Support a Protective Role for Lutein and Zeaxanthin in Delaying Chronic Disease. Overview J. Nutr., March 1, 2002; 132(3): 518S - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Palozza, S. Serini, N. Maggiano, M. Angelini, A. Boninsegna, F. Di Nicuolo, F. O. Ranelletti, and G. Calviello Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by {beta}-carotene through down-regulation of cyclin A and Bcl-2 family proteins Carcinogenesis, January 1, 2002; 23(1): 11 - 18. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
