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American Journal of Clinical Nutrition, Vol. 71, No. 2, 630S-636s, February 2000
© 2000 American Society for Clinical Nutrition

Supplement

Vitamin E and Alzheimer disease: the basis for additional clinical trials1,2,3

Michael Grundman

1 From the Alzheimer's Disease Cooperative Study, Department of Neurosciences, University of California, San Diego.

Many lines of evidence suggest that oxidative stress is important in the pathogenesis of Alzheimer disease. In particular, ß-amyloid, which is found abundantly in the brains of Alzheimer disease patients, is toxic in neuronal cell cultures through a mechanism involving free radicals. Vitamin E prevents the oxidative damage induced by ß-amyloid in cell culture and delays memory deficits in animal models. A placebo-controlled, clinical trial of vitamin E in patients with moderately advanced Alzheimer disease was conducted by the Alzheimer's Disease Cooperative Study. Subjects in the vitamin E group were treated with 2000 IU (1342 {alpha}-tocopherol equivalents) vitamin E/d. The results indicated that vitamin E may slow functional deterioration leading to nursing home placement. A new clinical trial is planned that will examine whether vitamin E can delay or prevent a clinical diagnosis of Alzheimer disease in elderly persons with mild cognitive impairment.

Key Words: Alzheimer disease • vitamin E • oxidative stress • free radicals • ß-amyloid • clinical trials • mild cognitive impairment • Alzheimer's Disease Cooperative Study • elderly




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