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Original Research Communications |
1 From the Institut für Physiologische Chemie I and Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine-Universität Düsseldorf, Germany; the Institut für Experimentelle Dermatologie, Universität Witten-Herdecke, Witten, Germany; and Krebsforschung Herdecke eV, Herdecke, Germany.
Background: Carotenoids and tocopherols, known to be efficient antioxidants and capable of scavenging reactive oxygen species generated during photooxidative stress, may protect the skin from ultraviolet light–induced erythema. ß-Carotene is widely used as an oral sun protectant but studies on its protective effects are scarce.
Objective: The objective of this study was to investigate the protective effects of oral supplementation with carotenoids and a combination of carotenoids and vitamin E against the development of erythema in humans.
Design: A carotenoid supplement (25 mg total carotenoids/d) and a combination of the carotenoid supplement and vitamin E [335 mg (500 IU) RRR-
-tocopherol/d] were given for 12 wk to healthy volunteers. Erythema was induced by illumination with a blue-light solar simulator. Serum ß-carotene and -tocopherol concentrations and skin carotenoid levels were assessed by HPLC and reflection photometry.
Results: Serum ß-carotene and -tocopherol concentrations increased with supplementation. Erythema on dorsal skin (back) was significantly diminished (P < 0.01) after week 8, and erythema suppression was greater with the combination of carotenoids and vitamin E than with carotenoids alone.
Conclusion: The antioxidants used in this study provided protection against erythema in humans and may be useful for diminishing sensitivity to ultraviolet light.
Key Words: Carotenoids • tocopherol • sunburn • skin • erythema • healthy adults • ultraviolet light
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