HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Westphal, S. Articles by Luley, C. Search for Related Content PubMed PubMed Citation Articles by Westphal, S. Articles by Luley, C. Agricola Articles by Westphal, S. Articles by Luley, C.

Postprandial chylomicrons and VLDLs in severe hypertriacylglycerolemia are lowered more effectively than are chylomicron remnants after treatment with n-3 fatty acids^1,2

¹ From the Institute of Clinical Chemistry, Magdeburg University Hospital, Magdeburg, Germany and Pronova Biocare, Lysaker, Norway.

Background: n-3 Fatty acids lower plasma triacylglycerols not only in the fasting state but also in the postprandial state. However, it is not known whether chylomicrons, chylomicron remnants, and VLDLs are all affected equally or whether some lipoprotein species are lowered preferentially.

Objective: Lipoproteins, including large and small chylomicron remnants, were determined specifically with the aid of a newly developed method involving a combination of size-exclusion chromatography and fluorometric determination of retinyl palmitate, which served as a marker for exogenous fat.

Design: Twelve hypertriacylglycerolemic men were treated for 6 wk with 4 capsules containing 85% fish-oil concentrate/d; each capsule contained 850 mg n-3 fatty acid ethyl esters (49.1% eicosapentaenoic acid by wt and 32.2% docosahexaenoic acid by wt). Oral-fat-tolerance tests were performed before and after the treatment. Blood samples were drawn in the fasting state and until 8 h postprandially.

Results: Treatment with n-3 fatty acids reduced the fasting VLDL-triacylglycerol concentration by 44% (P < 0.05) and postprandial chylomicrons and VLDLs at 4, 6, and 8 h (P < 0.05) by 49–64% and 36–43%, respectively. Chylomicron remnants were reduced only in the late postprandial phase: large chylomicron remnants by 19% at 6 h and by 43% at 8 h (P < 0.05) and small chylomicron remnants by 31% at 8 h (P < 0.05).

Conclusion: n-3 Fatty acids effectively lower chylomicrons and VLDLs, but their effect on chylomicron remnants was observed only in the late postprandial phase.

Key Words: n-3 Fatty acids • fish oil • hypertriacylglycerolemia • postprandial effects • lipoproteins • chylomicron remnants • chylomicrons • VLDL • men

This article has been cited by other articles:

				H. E. C. Hanwell, C. D. Kay, J. W. Lampe, B. J. Holub, and A. M. Duncan Acute Fish Oil and Soy Isoflavone Supplementation Increase Postprandial Serum (n-3) Polyunsaturated Fatty Acids and Isoflavones but Do Not Affect Triacylglycerols or Biomarkers of Oxidative Stress in Overweight and Obese Hypertriglyceridemic Men J. Nutr., June 1, 2009; 139(6): 1128 - 1134. [Abstract] [Full Text] [PDF]

				N. Collins, A. P. Tighe, S. A. Brunton, and P. M. Kris-Etherton Differences between Dietary Supplement and Prescription Drug Omega-3 Fatty Acid Formulations: A Legislative and Regulatory Perspective J. Am. Coll. Nutr., December 1, 2008; 27(6): 659 - 666. [Abstract] [Full Text] [PDF]

				T. A Jacobson Role of n-3 fatty acids in the treatment of hypertriglyceridemia and cardiovascular disease Am. J. Clinical Nutrition, June 1, 2008; 87(6): 1981S - 1990S. [Abstract] [Full Text] [PDF]

				J. M Malinowski and K. Metka Elevation of Low-Density Lipoprotein Cholesterol Concentration with Over-the-Counter Fish Oil Supplementation Ann. Pharmacother., July 1, 2007; 41(7): 1296 - 1300. [Abstract] [Full Text] [PDF]

				K. Vanschoonbeek, M. A. H. Feijge, W. H. M. Saris, M. P. M. de Maat, and J. W. M. Heemskerk Plasma Triacylglycerol and Coagulation Factor Concentrations Predict the Anticoagulant Effect of Dietary Fish Oil in Overweight Subjects J. Nutr., January 1, 2007; 137(1): 7 - 13. [Abstract] [Full Text] [PDF]

				L. F. Larsen, A. K. Olsen, A. K. Hansen, K. Bukhave, and P. Marckmann Feeding Minipigs Fish Oil for Four Weeks Lowers Postprandial Triacylglycerolemia J. Nutr., July 1, 2003; 133(7): 2273 - 2276. [Abstract] [Full Text] [PDF]

				D. C Chan, G. F Watts, T. A Mori, P H. R Barrett, T. G Redgrave, and L. J Beilin Randomized controlled trial of the effect of n-3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity Am. J. Clinical Nutrition, February 1, 2003; 77(2): 300 - 307. [Abstract] [Full Text] [PDF]