HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Daly, M. E Articles by Mathers, J. Search for Related Content PubMed PubMed Citation Articles by Daly, M. E Articles by Mathers, J. Agricola Articles by Daly, M. E Articles by Mathers, J.

Acute fuel selection in response to high-sucrose and high-starch meals in healthy men^1,2,3

¹ From the Human Nutrition Research Centre, the Department of Biological and Nutritional Sciences, the Human Diabetes and Metabolism Research Centre, and the Department of Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.

Background: Despite considerable controversy over the inclusion of sucrose in the diets of people with diabetes, the acute metabolism of sucrose is not completely understood.

Objective: Our objective was to investigate the metabolism of the monomeric constituents of sucrose after a high-sucrose meal.

Design: Three test meals were consumed in a randomized, crossover design by 7 healthy male volunteers. Two of the meals were high in sucrose; one was supplemented with 200 mg uniformly labeled [¹³C]fructose and one was supplemented with 200 mg [¹³C]glucose. The other meal was high in starch, supplemented with 200 mg [¹³C]glucose. Fifty percent of energy was supplied as sucrose in the high-sucrose meals and as starch in the high-starch meal. Breath ¹³CO₂ enrichment was measured at 15-min intervals and indirect calorimetry was performed for five 20-min sessions immediately before and during a 6-h postprandial period.

Results: Carbohydrate oxidation rates rose much faster after the high-sucrose meals than after the high-starch meal. Breath ¹³CO₂ enrichment rose faster and peaked earlier and at a higher value when [¹³C]fructose rather than [¹³C]glucose was given with the high-sucrose test meal. Values for breath ¹³CO₂ enrichment from [¹³C]glucose after the high-starch meal were intermediate.

Conclusions: These results show that fructose is preferentially oxidized compared with glucose after a high-sucrose meal and that glucose is oxidized more slowly after a high-sucrose meal than after a high-starch meal.

Key Words: Sucrose • fructose • starch • fuel selection • metabolic isotopes • diabetes • sucrose metabolism • carbohydrate oxidation • glucose oxidation • fructose oxidation • indirect calorimetry

This article has been cited by other articles:

				M. F-F Chong, B. A Fielding, and K. N Frayn Mechanisms for the acute effect of fructose on postprandial lipemia Am. J. Clinical Nutrition, June 1, 2007; 85(6): 1511 - 1520. [Abstract] [Full Text] [PDF]

				M. Daly Sugars, insulin sensitivity, and the postprandial state Am. J. Clinical Nutrition, October 1, 2003; 78(4): 865S - 872. [Abstract] [Full Text] [PDF]