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Original Research Communications |
1 From the School of Allied Health, University of Connecticut, Storrs; the Adult Clinical Research Center, Food and Nutritional Services, Internal Medicine, and Department of Nutritional Sciences, Yale New Haven Hospital, New Haven, CT; and the Yale University School of Internal Medicine, New Haven, CT.
Background: We reported previously that lowering dietary protein intake in young healthy women to 0.7 g/kg depressed intestinal calcium absorption and was accompanied by elevations in parathyroid hormone (PTH). Moderate amounts of dietary protein (1.0 g/kg) did not appear to perturb calcium homeostasis.
Objective: The purpose of this study was to evaluate the effect of graded intakes of dietary protein (0.7, 0.8, 0.9, and 1.0 g/kg) on calcium homeostasis.
Design: The experiment consisted of 2 wk of a well-balanced diet containing moderate amounts of calcium, sodium, and protein followed by 4 d of an experimental diet containing 1 of 4 amounts of protein. Eight young healthy women received the 4 amounts of protein in random order. The average age of the subjects was 23.1 ± 2.3 y, their weight was 64 ± 3 kg, and their body mass index (in kg/m2) was 24.3 ± 0.9.
Results: Elevations in PTH developed by day 4 of the diets containing 0.7 and 0.8 g protein/kg but not during the diets containing 0.9 or 1.0 g protein/kg. By day 4 of the 0.7- and 0.8-g/kg diets, midmolecule PTH, calcitriol, and nephrogenous cyclic adenosine monophosphate were 1.5–3.5-fold higher than on day 0. Calcitropic hormones on day 4 of the diets containing 0.8 and 0.9 g protein/kg were within the normal range and 23–57% lower than values observed with the 0.7- and 0.8-g/kg diets (P < 0.005). Mean 24-h urinary calcium was 3.29 ± 0.35 mmol with the diet containing 0.7 g protein/kg and 3.54 ± 0.46 mmol with the diet containing 1.0 g protein/kg.
Conclusions: Our data suggest that in young healthy women consuming a well-balanced diet, the current recommended dietary allowance for protein (0.8 g/kg) results in short-term perturbations in calcium homeostasis.
Key Words: Dietary protein • calcium metabolism • calcitropic hormones • vitamin D • parathyroid hormone • young healthy women • recommended dietary allowance
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