| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communications |
1 From the Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, and the Child Nutrition Research Centre, Flinders Medical Centre, Bedford Park, Australia.
Background: Results of many studies indicate that consumption of n-3 fatty acids can benefit persons with cardiovascular disease and rheumatoid arthritis. However, encapsulated fish oil is unlikely to be suited to lifetime daily use and recommendations to increase fish intake have not been effective.
Objective: The objective was to examine the effectiveness of a diet that incorporates foods rich in n-3 fatty acids in elevating tissue concentrations of eicosapentaenoic acid and in suppressing the production of inflammatory mediators.
Design: Healthy male volunteers were provided with foods that were enriched in 
-linolenic acid (cooking oil, margarine, salad dressing, and mayonnaise) and eicosapentaenoic and docosahexaenoic acids (sausages and savory dip) and with foods naturally rich in n-3 fatty acids, such as flaxseed meal and fish. Subjects incorporated these products into their food at home for 4 wk. Fatty acid intakes, cellular and plasma fatty acid concentrations, and monocyte-derived eicosanoid and cytokine production were measured.
Results: Analyses of dietary records indicated that intake of eicosapentaenoic acid plus docosahexaenoic acid averaged 1.8 g/d and intake of -linolenic acid averaged 9.0 g/d. These intakes led to an average 3-fold increase in eicosapentaenoic acid in plasma, platelet, and mononuclear cell phospholipids. Thromboxane B2, prostaglandin E2, and interleukin 1ß synthesis decreased by 36%, 26%, and 20% (P < 0.05), respectively.
Conclusions: Foods that are strategically or naturally enriched in n-3 fatty acids can be used to achieve desired biochemical effects without the ingestion of supplements or a change in dietary habits. A wide range of n-3-enriched foods could be developed to support large-scale programs on the basis of the therapeutic and disease-preventive effects of n-3 fatty acids.
Key Words: -Linolenic acid • eicosapentaenoic acid • docosahexaenoic acid • n-3 fatty acids • n-3 fatty acid–rich foods • cytokines • eicosanoids • men
This article has been cited by other articles:
|
|
 |
|
  I. Aeberli, L. Molinari, G. Spinas, R. Lehmann, D. l'Allemand, and M. B Zimmermann Dietary intakes of fat and antioxidant vitamins are predictors of subclinical inflammation in overweight Swiss children. Am. J. Clinical Nutrition, October 1, 2006; 84(4): 748 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Zararsiz, M. F. Sonmez, H. R. Yilmaz, U. Tas, I. Kus, A. Kavakli, and M. Sarsilmaz Effects of v-3 essential fatty acids against formaldehyde-induced nephropathy in rats Toxicology and Industrial Health, June 1, 2006; 22(5): 223 - 229. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Ferrucci, A. Cherubini, S. Bandinelli, B. Bartali, A. Corsi, F. Lauretani, A. Martin, C. Andres-Lacueva, U. Senin, and J. M. Guralnik Relationship of Plasma Polyunsaturated Fatty Acids to Circulating Inflammatory Markers J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 439 - 446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ladetto, S. Vallet, A. Trojan, M. Dell'Aquila, L. Monitillo, R. Rosato, L. Santo, D. Drandi, A. Bertola, P. Falco, et al. Cyclooxygenase-2 (COX-2) is frequently expressed in multiple myeloma and is an independent predictor of poor outcome Blood, June 15, 2005; 105(12): 4784 - 4791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Jia, H.-R. Zhou, M. Bennink, and J. J. Pestka Docosahexaenoic Acid Attenuates Mycotoxin-Induced Immunoglobulin A Nephropathy, Interleukin-6 Transcription, and Mitogen-Activated Protein Kinase Phosphorylation in Mice J. Nutr., December 1, 2004; 134(12): 3343 - 3349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kew, M. D Mesa, S. Tricon, R. Buckley, A. M Minihane, and P. Yaqoob Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humans Am. J. Clinical Nutrition, April 1, 2004; 79(4): 674 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. M. Ursin Modification of Plant Lipids for Human Health: Development of Functional Land-Based Omega-3 Fatty Acids J. Nutr., December 1, 2003; 133(12): 4271 - 4274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Song, X. Li, B. E. Leonard, and D. F. Horrobin Effects of dietary n-3 or n-6 fatty acids on interleukin-1{beta}-induced anxiety, stress, and inflammatory responses in rats J. Lipid Res., October 1, 2003; 44(10): 1984 - 1991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J James, V. M Ursin, and L. G Cleland Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1140 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Kramer, J. LeDeaux, D. Butteiger, T. Young, C. Crankshaw, H. Harlow, L. Kier, and B. G. Bhat Transcription Profiling in Rat Liver in Response to Dietary Docosahexaenoic Acid Implicates Stearoyl-Coenzyme A Desaturase as a Nutritional Target for Lipid Lowering J. Nutr., January 1, 2003; 133(1): 57 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Bemelmans, J. Broer, E. J. Feskens, A. J Smit, F. A. Muskiet, J. D Lefrandt, V. J. Bom, J. F May, and B. Meyboom-de Jong Effect of an increased intake of {alpha}-linolenic acid and group nutritional education on cardiovascular risk factors: the Mediterranean Alpha-linolenic Enriched Groningen Dietary Intervention (MARGARIN) study Am. J. Clinical Nutrition, February 1, 2002; 75(2): 221 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. MADANI, A. HICHAMI, A. LEGRAND, J. BELLEVILLE, and N. A. KHAN Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C FASEB J, December 1, 2001; 15(14): 2595 - 2601. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
