| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communications |
1 From the Department of Nutrition and Food Management, Oregon State University, Corvallis.
Background: It is generally thought that as the intake of dietary polyunsaturated fatty acids increases, so should that of 
-tocopherol, to protect the polyunsaturated fatty acids from increased in vivo peroxidation. However, there are little quantitative data about the concentration of -tocopherol that is necessary when eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are consumed.
Objective: The purpose of this study was to measure changes produced in 2 indexes of lipid oxidation after supplementation with EPA and DHA from fish oil and 3 doses of RRR--tocopheryl acetate in postmenopausal women.
Design: Daily supplements of fish oil providing 2.5 g EPA and 1.8 g DHA and 0, 100, 200, or 400 mg -tocopheryl acetate were given to 46 postmenopausal women in a 4-treatment, 4-period crossover design.
Results: The supplements increased plasma concentrations of EPA, DHA, and -tocopherol. The fish-oil supplement increased the plasma concentration of thiobarbituric acid–reactive substances (TBARS) (P = 0.0001) but not that of oxidatively modified protein, as indicated by the carbonyl content. The -tocopheryl acetate and fish-oil supplements had no significant effect on plasma concentrations of TBARS or oxidized protein.
Conclusions: Although these data show a small but statistically significant increase in oxidative stress on the basis of plasma TBARS concentrations after the consumption of EPA and DHA, the clinical relevance of this change is questionable. In addition, as supplements of -tocopheryl acetate were added to the diet, neither the plasma TBARS concentration nor the protein oxidation changed. Consequently, the results of this study indicate that there is no basis for vitamin E supplementation after consumption of EPA and DHA.
Key Words: Postmenopausal women • thiobarbituric acid reactive substances • TBARS • fish oil • lipid oxidation • protein oxidation • vitamin E
This article has been cited by other articles:
|
|
 |
|
  M. Iraz, H. Erdogan, B. Ozyurt, F. Ozugurlu, S. Ozgocmen, and E. Fadillioglu Omega-3 Essential Fatty Acid Supplementation and Erythrocyte Oxidant/Antioxidant Status in Rats Ann. Clin. Lab. Sci., April 1, 2005; 35(2): 169 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mishra, A. Chaudhary, and S. Sethi Oxidized Omega-3 Fatty Acids Inhibit NF-{kappa}B Activation Via a PPAR{alpha}-Dependent Pathway Arterioscler. Thromb. Vasc. Biol., September 1, 2004; 24(9): 1621 - 1627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Goel, T. G. Maddaford, and G. N. Pierce Effects of omega -3 polyunsaturated fatty acids on cardiac sarcolemmal Na+/H+ exchange Am J Physiol Heart Circ Physiol, October 1, 2002; 283 (4): H1688 - H1694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sethi, O. Ziouzenkova, H. Ni, D. D. Wagner, J. Plutzky, and T. N. Mayadas Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPARalpha Blood, July 30, 2002; 100(4): 1340 - 1346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. V Higdon, J. Liu, S.-H. Du, J. D Morrow, B. N Ames, and R. C Wander Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F2-isoprostanes Am. J. Clinical Nutrition, September 1, 2000; 72(3): 714 - 722. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
