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Original Research Communications |
1 From the Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, the Department of Statistics, Iowa State University, Ames, and the Research and Development Laboratory, Fujicco Co, Ltd, Kobe Hyogo, Japan.
Background: No published studies have directly examined the effect of soy protein with isoflavones on bone or bone turnover in perimenopausal women.
Objective: Our objective was to determine the effects of 24 wk of consumption of soy protein isolate with isoflavones (80.4 mg/d) in attenuating bone loss during the menopausal transition.
Design: Perimenopausal subjects were randomly assigned, double blind, to treatment: isoflavone-rich soy (SPI+; n = 24), isoflavone-poor soy (SPI-; n = 24), or whey (control; n = 21) protein. At baseline and posttreatment, lumbar spine bone mineral density (BMD) and bone mineral content (BMC) were measured by using dual-energy X-ray absorptiometry. At baseline, midtreatment, and posttreatment, urinary N-telopeptides and serum bone-specific alkaline phosphatase (BAP) were measured.
Results: The percentage change in lumbar spine BMD and BMC, respectively, did not differ from zero in the SPI+ or SPI- groups, but loss occurred in the control group (-1.28%, P = 0.0041; -1.73%, P = 0.0037). By regression analysis, SPI+ treatment had a positive effect on change in BMD (5.6%; P = 0.023) and BMC (10.1%; P = 0.0032). Baseline BMD and BMC (P 
0.0001) negatively affected the percentage change in their respective models; baseline body weight (P = 0.0036) and bone-free lean weight (P = 0.016) contributed positively to percentage change in BMD and BMC, respectively. Serum BAP posttreatment was negatively related to percentage change in BMD (P = 0.0016) and BMC (P = 0.019). Contrast coding using analyses of covariance with BMD or BMC as the outcome showed that isoflavones, not soy protein, exerted the effect.
Conclusion: Soy isoflavones attenuated bone loss from the lumbar spine in perimenopausal women.
Key Words: Soy • isoflavones • bone density • lumbar vertebrae • biochemical markers • menopause • bone mineral content • perimenopausal women
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K. D. R. Setchell Soy Isoflavones--Benefits and Risks from Nature's Selective Estrogen Receptor Modulators (SERMs) J. Am. Coll. Nutr., October 1, 2001; 20(90005): 354S - 362. [Abstract] [Full Text]
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B. H. Arjmandi The Role of Phytoestrogens in the Prevention and Treatment of Osteoporosis in Ovarian Hormone Deficiency J. Am. Coll. Nutr., October 1, 2001; 20(90005): 398S - 402. [Abstract] [Full Text]
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S. B. Dent, C. T. Peterson, L. D. Brace, J. H. Swain, M. B. Reddy, K. B. Hanson, J. G. Robinson, and D. L. Alekel Soy Protein Intake by Perimenopausal Women Does Not Affect Circulating Lipids and Lipoproteins or Coagulation and Fibrinolytic Factors J. Nutr., September 1, 2001; 131(9): 2280 - 2287. [Abstract] [Full Text] [PDF]
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B. Anderson; Soy Phytoestrogens, Lipid Reductions, and Atherosclerosis Delay in Ovariectomized Primates J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 39 - 40. [Full Text]
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J. W Erdman Jr, R. J Stillman, and R. A Boileau Provocative relation between soy and bone maintenance Am. J. Clinical Nutrition, September 1, 2000; 72(3): 679 - 680. [Full Text] [PDF]
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