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American Journal of Clinical Nutrition, Vol. 72, No. 5, 1107-1110, November 2000
© 2000 American Society for Clinical Nutrition

Original Research Communication

Heavy coffee consumption and plasma homocysteine: a randomized controlled trial in healthy volunteers1,2,3

Rob Urgert, Trinette van Vliet, Peter L Zock and Martijn B Katan

1 From the Wageningen Centre for Food Sciences, Nutrition and Health Programme, Wageningen, Netherlands; the Department of Physiology, TNO Nutrition and Food Research Institute, Zeist, Netherlands; and the Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, Netherlands.

Background: An elevated plasma concentration of total homocysteine is considered to be a strong risk factor for cardiovascular disease. Heavy coffee drinking has been related to high homocysteine concentrations in epidemiologic studies and in one experiment in which healthy subjects drank unfiltered, boiled coffee.

Objective: Our goal was to determine whether daily consumption of paper-filtered coffee raises plasma concentrations of total homocysteine in healthy subjects.

Design: Twenty-six volunteers (18–53 y of age) consumed 1 L/d of paper-filtered coffee brewed with 70 g regular ground beans or no coffee for 4 wk each in a randomized, crossover design.

Results: The mean (±SD) plasma concentration of total homocysteine in fasting blood was 8.1 ± 1.8 µmol/L after abstention from coffee and 9.6 ± 2.9 µmol/L after 3–4 wk of coffee drinking, a difference of 1.5 µmol/L (95% CI: 0.9, 2.1 µmol/L) or 18% (P < 0.001). Coffee increased homocysteine concentrations in 24 of 26 individuals. Circulating concentrations of vitamin B-6, vitamin B-12, and folate were unaffected.

Conclusion: Drinking large quantities of paper-filtered coffee raises fasting plasma concentrations of total homocysteine in healthy individuals.

Key Words: Coffee consumption • homocysteine metabolism • dietary factors • crossover experiment • risk factors




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