HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Brynes, A. E Articles by Frost, G. S Search for Related Content PubMed PubMed Citation Articles by Brynes, A. E Articles by Frost, G. S Agricola Articles by Brynes, A. E Articles by Frost, G. S

Diet-induced change in fatty acid composition of plasma triacylglycerols is not associated with change in glucagon-like peptide 1 or insulin sensitivity in people with type 2 diabetes^1,2,3

¹ From the Nutrition and Dietetic Research Group, the Endocrine Unit, and the Lipoprotein Team, Imperial College School of Medicine, Hammersmith Hospital, London.

Background: Polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs) have been shown to positively affect blood lipids; however, their comparative effects on insulin sensitivity are unclear.

Objective: Our objective was to investigate whether chronic intake of MUFAs or PUFAs improves insulin sensitivity in people with type 2 diabetes via stimulation of the endogenous gut hormone glucagon-like peptide 1 [7–36] amide (GLP-1).

Design: Nine overweight people with type 2 diabetes received isoenergetic high-MUFA (20.3 ± 3.5% of total energy) or high-PUFA (13.4 ± 1.3%) diets for 24 d in a randomized, double-blind crossover design.

Results: Weight and glycemic control remained stable throughout the study. Despite a significant change in the plasma triacylglycerol linoleic-oleic acid ratio (L:O) with both diets (MUFA: from 0.46 ± 0.03 to 0.29 ± 0.02, P < 0.005; PUFA: from 0.36 ± 0.04 to 0.56 ± 0.05, P < 0.05) and the phospholipid L:O (1.7 ± 0.1 to 2.0 ± 0.3; P = 0.04) during consumption of the PUFA diet, this change was not associated with a change in insulin sensitivity, measured by the short-insulin-tolerance test. There was a significant reduction in the ratio of total to HDL cholesterol during consumption of the PUFA diet (5.2 ± 0.4 compared with 4.7 ± 0.3; P = 0.005) but no change with the MUFA diet. There was no change in the fasting or postprandial incremental area under the curve in response to an identical standard test meal for glucose, insulin, triacylglycerol, nonesterified fatty acids, or GLP-1.

Conclusions: Over the 3-wk intervention period, diet-induced change in the triacylglycerol or phospholipid L:O was not associated with either increased stimulation of GLP-1 or a change in insulin sensitivity in people with type 2 diabetes.

Key Words: MUFA • PUFA • insulin sensitivity • GLP-1 • type 2 diabetes • monounsaturated fatty acids • polyunsaturated fatty acids • glucagon-like peptide 1 [7–36] amide • triacylglycerol • cholesterol

This article has been cited by other articles:

				C.-W. Chen and H.-H. Cheng A Rice Bran Oil Diet Increases LDL-Receptor and HMG-CoA Reductase mRNA Expressions and Insulin Sensitivity in Rats with Streptozotocin/Nicotinamide-Induced Type 2 Diabetes J. Nutr., June 1, 2006; 136(6): 1472 - 1476. [Abstract] [Full Text] [PDF]

				P. D. Dworatzek, R. A Hegele, and T. M. Wolever Postprandial lipemia in subjects with the threonine 54 variant of the fatty acid-binding protein 2 gene is dependent on the type of fat ingested Am. J. Clinical Nutrition, June 1, 2004; 79(6): 1110 - 1117. [Abstract] [Full Text] [PDF]

				C. Thomsen, H. Storm, J. J Holst, and K. Hermansen Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes Am. J. Clinical Nutrition, March 1, 2003; 77(3): 605 - 611. [Abstract] [Full Text] [PDF]

				J. C. Lovejoy, S. R. Smith, C. M. Champagne, M. M. Most, M. Lefevre, J. P. DeLany, Y. M. Denkins, J. C. Rood, J. Veldhuis, and G. A. Bray Effects of Diets Enriched in Saturated (Palmitic), Monounsaturated (Oleic), or trans (Elaidic) Fatty Acids on Insulin Sensitivity and Substrate Oxidation in Healthy Adults Diabetes Care, August 1, 2002; 25(8): 1283 - 1288. [Abstract] [Full Text] [PDF]

				M. Garaulet, F. Perez-Llamas, M. Perez-Ayala, P. Martinez, F. S. de Medina, F. J Tebar, and S. Zamora Site-specific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area: relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity Am. J. Clinical Nutrition, November 1, 2001; 74(5): 585 - 591. [Abstract] [Full Text] [PDF]