| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Supplement |
1 From the UCL-Université catholique de Louvain, School of Pharmacy, Brussels.
Several nondigestible but fermentable dietary carbohydrates are able to regulate lipemia and triglyceridemia in both humans and animals. The mechanism of their serum lipid–lowering effect remains to be elucidated. Oligofructose, which is a mixture of nondigestible and fermentable fructans, can decrease triacylglycerol in VLDL when given to rats. The triacylglycerol-lowering action of oligofructose is due to a reduction of de novo fatty acid synthesis in the liver through inhibition of all lipogenic enzymes, namely acetyl-CoA carboxylase (EC 6.4.1.2), fatty acid synthase, malic enzyme (EC 1.1.1.40), ATP citrate lyase (EC 4.1.3.8), and glucose-6-phosphate dehydrogenase (EC 1.1.1.49). Our results suggest that oligofructose decreases lipogenic enzyme gene expression. Postprandial insulin and glucose concentrations are low in the serum of oligofructose-fed animals and this could explain, at least partially, the metabolic effect of oligofructose. Moreover, some events occurring in the gastrointestinal tract after oligofructose feeding could be involved in the antilipogenic effect of this fructan: the production of propionate through fermentation, a modulation of the intestinal production of incretins (namely glucose-dependent insulinotropic peptide and glucagon-like peptide-1), or the modification of the availability of digestible carbohydrates. Recent studies showed that the hypotriglyceridemic effect of fructans also occurs in humans.
Key Words: Triacylglycerol • lipogenesis • fructans • rat • liver
This article has been cited by other articles:
|
|
 |
|
  A. D. Maurer, Q. Chen, C. McPherson, and R. A. Reimer Changes in satiety hormones and expression of genes involved in glucose and lipid metabolism in rats weaned onto diets high in fibre or protein reflect susceptibility to increased fat mass in adulthood J. Physiol., February 1, 2009; 587(3): 679 - 691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Salazar, M. Gueimonde, A. M. Hernandez-Barranco, P. Ruas-Madiedo, and C. G. de los Reyes-Gavilan Exopolysaccharides Produced by Intestinal Bifidobacterium Strains Act as Fermentable Substrates for Human Intestinal Bacteria Appl. Envir. Microbiol., August 1, 2008; 74(15): 4737 - 4745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Benyacoub, F. Rochat, K.-Y. Saudan, I. Rochat, N. Antille, C. Cherbut, T. von der Weid, E. J. Schiffrin, and S. Blum Feeding a Diet Containing a Fructooligosaccharide Mix Can Enhance Salmonella Vaccine Efficacy in Mice J. Nutr., January 1, 2008; 138(1): 123 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Finley, J. B. Burrell, and P. G. Reeves Pinto Bean Consumption Changes SCFA Profiles in Fecal Fermentations, Bacterial Populations of the Lower Bowel, and Lipid Profiles in Blood of Humans J. Nutr., November 1, 2007; 137(11): 2391 - 2398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Vogt, K. B. Ishii-Schrade, P. B. Pencharz, P. J. H. Jones, and T. M. S. Wolever L-Rhamnose and Lactulose Decrease Serum Triacylglycerols and Their Rates of Synthesis, but Do Not Affect Serum Cholesterol Concentrations in Men J. Nutr., August 1, 2006; 136(8): 2160 - 2166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Liong and N. P. Shah Effects of a Lactobacillus casei Synbiotic on Serum Lipoprotein, Intestinal Microflora, and Organic Acids in Rats J Dairy Sci, May 1, 2006; 89(5): 1390 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-K. Hsu, J.-W. Liao, Y.-C. Chung, C.-P. Hsieh, and Y.-C. Chan Xylooligosaccharides and Fructooligosaccharides Affect the Intestinal Microbiota and Precancerous Colonic Lesion Development in Rats J. Nutr., June 1, 2004; 134(6): 1523 - 1528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Busserolles, E. Gueux, E. Rock, C. Demigne, A. Mazur, and Y. Rayssiguier Oligofructose Protects against the Hypertriglyceridemic and Pro-oxidative Effects of a High Fructose Diet in Rats J. Nutr., June 1, 2003; 133(6): 1903 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Letexier, F. Diraison, and M. Beylot Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans Am. J. Clinical Nutrition, March 1, 2003; 77(3): 559 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Busserolles, E. Gueux, E. Rock, A. Mazur, and Y. Rayssiguier Substituting Honey for Refined Carbohydrates Protects Rats from Hypertriglyceridemic and Prooxidative Effects of Fructose J. Nutr., November 1, 2002; 132(11): 3379 - 3382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B Roberfroid Prebiotics: preferential substrates for specific germs? Am. J. Clinical Nutrition, February 1, 2001; 73(2): 406S - 409. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
