HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Erkkilä, A. T Articles by Uusitupa, M. I. Search for Related Content PubMed PubMed Citation Articles by Erkkilä, A. T Articles by Uusitupa, M. I. Agricola Articles by Erkkilä, A. T Articles by Uusitupa, M. I.

APOE polymorphism and the hypertriglyceridemic effect of dietary sucrose^1,2,3

¹ From the Departments of Clinical Nutrition and Medicine, University of Kuopio, Kuopio, Finland.

Background: The E4 allele of the apolipoprotein gene (APOE) is associated with a greater serum cholesterol response to dietary changes in fat and cholesterol. However, less is known about the interaction between APOE polymorphism and other macronutrients in the diet.

Objective: We evaluated the interaction between APOE polymorphism and dietary fat and carbohydrate, particularly sucrose, in relation to serum lipid concentrations.

Design: A total of 284 men and 130 women with coronary artery disease (mean age: 61 y; range: 33–74 y) participated in the cross-sectional EUROASPIRE study. Serum lipids and fatty acids in cholesteryl esters (CEs) were measured and APOE genotypes were determined. Dietary intake was examined by using a 4-d food record.

Results: Patients were grouped by APOE genotype: E2 (E2/E2 and E2/E3; n = 21), E3 (E3/E3; n = 245), and E4 (E4/E2, E4/E3, and E4/E4; n = 148). Patients with the E2 allele had lower LDL-cholesterol concentrations and tended to have higher triacylglycerol concentrations than did patients with the E3 or E4 allele; concentrations were not significantly different between the last 2 groups. In regression analysis, significant predictors of serum triacylglycerol were the interaction between sucrose intake and the E2 allele, proportion of n-3 fatty acids in CEs, body mass index, and diabetes. A high sucrose intake was associated with high triacylglycerol concentrations only in patients with the E2 allele. Interaction between saturated fat intake and the E2 allele, proportion of linoleic acid in CEs, and fiber intake predicted serum cholesterol.

Conclusion: Coronary artery disease patients with the E2 allele will likely have a greater triacylglycerol response to high dietary sucrose intakes than will patients with the E3 or E4 allele.

Key Words: Apolipoprotein E • APOE polymorphism • diet • serum lipids • triacylglycerol • cholesterol • coronary artery disease • EUROASPIRE • European Action on Secondary Prevention through Intervention to Reduce Events

This article has been cited by other articles:

				S. K Fried and S. P Rao Sugars, hypertriglyceridemia, and cardiovascular disease Am. J. Clinical Nutrition, October 1, 2003; 78(4): 873S - 880. [Abstract] [Full Text] [PDF]

				E. Ros Dietary cis-monounsaturated fatty acids and metabolic control in type 2 diabetes Am. J. Clinical Nutrition, September 1, 2003; 78(3): 617S - 625. [Abstract] [Full Text] [PDF]

				L. Berglund The APOE gene and diets--food (and drink) for thought Am. J. Clinical Nutrition, April 1, 2001; 73(4): 669 - 670. [Full Text] [PDF]